(R)-methyl 4-(2-fluorophenyl)-2-hydroxy-2-(trifluoromethyl)pent-4-enoate

Base Information

• Chemical Name: (R)-methyl 4-(2-fluorophenyl)-2-hydroxy-2-(trifluoromethyl)pent-4-enoate
• CAS No.: 1198746-13-2
• Molecular Formula: C₁₃H₁₂F₄O₃
• Molecular Weight: 292.23
• Mol file: 1198746-13-2.mol

Synonyms:(R)-methyl 4-(2-fluorophenyl)-2-hydroxy-2-(trifluoromethyl)pent-4-enoate

Chemical Property of (R)-methyl 4-(2-fluorophenyl)-2-hydroxy-2-(trifluoromethyl)pent-4-enoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of (R)-methyl 4-(2-fluorophenyl)-2-hydroxy-2-(trifluoromethyl)pent-4-enoate

There total 2 articles about (R)-methyl 4-(2-fluorophenyl)-2-hydroxy-2-(trifluoromethyl)pent-4-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-fluoro-2-(prop-1-en-2-yl)benzene (344-73-0) + trifluoromethylpyruvate → (R)-methyl 4-(2-fluorophenyl)-2-hydroxy-2-(trifluoromethyl)pent-4-enoate (1198746-13-2)

Guidance literature:

With 2,6-bis[(3aR,8aS)-3a,8a-dihydro-8H-indeno[1,2-d]oxazolin-2-yl]pyridine; indium(III) chloride; silver hexafluoroantimonate; In 1,2-dichloro-ethane; at 20 ℃; optical yield given as %ee; enantioselective reaction; Ionic liquid; Molecular sieve;

DOI:10.1002/adsc.201000170

Reference yield:

methyl 3,3,3-trifluoropyruvate (13089-11-7) → (R)-methyl 4-(2-fluorophenyl)-2-hydroxy-2-(trifluoromethyl)pent-4-enoate (1198746-13-2) + (S)-methyl 4-(2-fluorophenyl)-2-hydroxy-2-(trifluoromethyl)pent-4-enoate

Guidance literature:

With 2,6-bis[(3aR,8aS)-3a,8a-dihydro-8H-indeno[1,2-d]oxazolin-2-yl]pyridine; indium(III) chloride; silver hexafluoroantimonate; In 1,2-dichloro-ethane; at 20 ℃; for 240h; optical yield given as %ee; enantioselective reaction; Molecular sieve; Inert atmosphere;

DOI:10.1021/ol902507x

upstream raw materials:

methyl 3,3,3-trifluoropyruvate

1-fluoro-2-(prop-1-en-2-yl)benzene