1-(4-(trifluoromethylthio)phenyl)-3-(5-chloro-1,3-dimethyl-1H-pyrazole-4-carbonyl)thiourea

Base Information

• Chemical Name: 1-(4-(trifluoromethylthio)phenyl)-3-(5-chloro-1,3-dimethyl-1H-pyrazole-4-carbonyl)thiourea
• CAS No.: 1392131-62-2
• Molecular Formula: C₁₄H₁₂ClF₃N₄OS₂
• Molecular Weight: 408.856
• Mol file: 1392131-62-2.mol

Synonyms:1-(4-(trifluoromethylthio)phenyl)-3-(5-chloro-1,3-dimethyl-1H-pyrazole-4-carbonyl)thiourea

Chemical Property of 1-(4-(trifluoromethylthio)phenyl)-3-(5-chloro-1,3-dimethyl-1H-pyrazole-4-carbonyl)thiourea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-(trifluoromethylthio)phenyl)-3-(5-chloro-1,3-dimethyl-1H-pyrazole-4-carbonyl)thiourea

There total 5 articles about 1-(4-(trifluoromethylthio)phenyl)-3-(5-chloro-1,3-dimethyl-1H-pyrazole-4-carbonyl)thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.4%

thioorthocarbonotrifluoridic acid 4-amino-phenyl ester (372-16-7) + C7H6ClN3OS (357204-44-5) → 1-(4-(trifluoromethylthio)phenyl)-3-(5-chloro-1,3-dimethyl-1H-pyrazole-4-carbonyl)thiourea (1392131-62-2)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 4h;

DOI:10.3390/molecules17055139

Reference yield:

5-chloro-4-formyl-1,3-dimethylpyrazole (27006-76-4) → 1-(4-(trifluoromethylthio)phenyl)-3-(5-chloro-1,3-dimethyl-1H-pyrazole-4-carbonyl)thiourea (1392131-62-2)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium permanganate / water

2: thionyl chloride / 4 h / 80 °C

3: PEG-400 / acetonitrile / 3 h / 25 °C

4: tetrahydrofuran / 4 h / 20 °C

With potassium permanganate; thionyl chloride; In tetrahydrofuran; water; acetonitrile;

DOI:10.3390/molecules17055139

Reference yield:

1,3-dimethyl-5-pyrazolone (2749-59-9) → 1-(4-(trifluoromethylthio)phenyl)-3-(5-chloro-1,3-dimethyl-1H-pyrazole-4-carbonyl)thiourea (1392131-62-2)

Guidance literature:

Multi-step reaction with 5 steps

1: trichlorophosphate

2: potassium permanganate / water

3: thionyl chloride / 4 h / 80 °C

4: PEG-400 / acetonitrile / 3 h / 25 °C

5: tetrahydrofuran / 4 h / 20 °C

With potassium permanganate; thionyl chloride; trichlorophosphate; In tetrahydrofuran; water; acetonitrile;

DOI:10.3390/molecules17055139

upstream raw materials:

thioorthocarbonotrifluoridic acid 4-amino-phenyl ester

C₇H₆ClN₃OS

1,3-dimethyl-5-pyrazolone

5-chloro-4-formyl-1,3-dimethylpyrazole