(4S,6E)-1-tert-butyldimethylsilyloxy-4-tert-butyldiphenylsilyloxy-6-octene

Base Information

Chemical Name:(4S,6E)-1-tert-butyldimethylsilyloxy-4-tert-butyldiphenylsilyloxy-6-octene
CAS No.:866138-92-3
Molecular Formula:C₃₀H₄₈O₂Si₂
Molecular Weight:496.881
Hs Code.:

Synonyms:(4S,6E)-1-tert-butyldimethylsilyloxy-4-tert-butyldiphenylsilyloxy-6-octene

Suppliers and Price of (4S,6E)-1-tert-butyldimethylsilyloxy-4-tert-butyldiphenylsilyloxy-6-octene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4S,6E)-1-tert-butyldimethylsilyloxy-4-tert-butyldiphenylsilyloxy-6-octene

Chemical Property:

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Technology Process of (4S,6E)-1-tert-butyldimethylsilyloxy-4-tert-butyldiphenylsilyloxy-6-octene

There total 6 articles about (4S,6E)-1-tert-butyldimethylsilyloxy-4-tert-butyldiphenylsilyloxy-6-octene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 866138-80-9
(4S,6E)-1-(tert-butyldimethylsilyloxy)oct-6-en-4-ol

: 58479-61-1
tert-butylchlorodiphenylsilane

: 866138-92-3
(4S,6E)-1-tert-butyldimethylsilyloxy-4-tert-butyldiphenylsilyloxy-6-octene

Guidance literature:: With 1H-imidazole; dmap; In dichloromethane; at 20 ℃; for 5h;
DOI:10.1021/ol051200o

Reference yield:

: 32780-06-6
(5S)-5-(hydroxymethyl)-2-oxo-tetrahydrofuran

: 866138-92-3
(4S,6E)-1-tert-butyldimethylsilyloxy-4-tert-butyldiphenylsilyloxy-6-octene

Guidance literature:: Multi-step reaction with 6 steps

1: 95 percent / DIBALH / tetrahydrofuran; hexane / -78 - 20 °C

2: 92 percent / Et₃N; DMAP / CH₂Cl₂ / 5 h / 20 °C

3: 95 percent / NaH / tetrahydrofuran / 2 h / 20 °C

4: 99 percent / Li; CuCN / diethyl ether; tetrahydrofuran / -78 - 0 °C

5: 92 percent / imidazole; DMAP / CH₂Cl₂ / 5 h / 20 °C

With 1H-imidazole; dmap; lithium; sodium hydride; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; diethyl ether; hexane; dichloromethane;
DOI:10.1021/ol051200o

Reference yield:

: 866138-79-6
(2S)-5-{[(tert-butyl)(dimethyl)silyl]oxy}-2-hydroxypentyl 4-methylbenzenesulfonate

: 866138-92-3
(4S,6E)-1-tert-butyldimethylsilyloxy-4-tert-butyldiphenylsilyloxy-6-octene

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / NaH / tetrahydrofuran / 2 h / 20 °C

2: 99 percent / Li; CuCN / diethyl ether; tetrahydrofuran / -78 - 0 °C

3: 92 percent / imidazole; DMAP / CH₂Cl₂ / 5 h / 20 °C

With 1H-imidazole; dmap; lithium; sodium hydride; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/ol051200o