tert-butyl 7-[2-((Z)-3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylamino]-4-oxo-4H-furo[2,3-c]chromene-6-carboxylate

Base Information

Chemical Name:tert-butyl 7-[2-((Z)-3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylamino]-4-oxo-4H-furo[2,3-c]chromene-6-carboxylate
CAS No.:1356112-77-0
Molecular Formula:C₂₉H₃₁FN₂O₇S
Molecular Weight:570.639
Hs Code.:

Synonyms:tert-butyl 7-[2-((Z)-3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylamino]-4-oxo-4H-furo[2,3-c]chromene-6-carboxylate

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Chemical Property of tert-butyl 7-[2-((Z)-3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylamino]-4-oxo-4H-furo[2,3-c]chromene-6-carboxylate

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Technology Process of tert-butyl 7-[2-((Z)-3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylamino]-4-oxo-4H-furo[2,3-c]chromene-6-carboxylate

There total 11 articles about tert-butyl 7-[2-((Z)-3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylamino]-4-oxo-4H-furo[2,3-c]chromene-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 681247-87-0,681247-88-1
N,N-diethyl-N-((Z)-1-tributylstannanylprop-1-en-3-yl)-amine

: 1356112-79-2
tert-butyl 7-(2-bromo-4-fluorobenzenesulfonylamino)-4-oxo-4H-furo[2,3-c]chromene-6-carboxylate

: 1356112-77-0
tert-butyl 7-[2-((Z)-3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylamino]-4-oxo-4H-furo[2,3-c]chromene-6-carboxylate

Guidance literature:: With tri tert-butylphosphoniumtetrafluoroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; at 95 ℃; for 1.25h; Inert atmosphere;

Reference yield:

: 681247-11-0
methyl 6-amino-3-bromo-2-hydroxybenzoate

: 1356112-77-0
tert-butyl 7-[2-((Z)-3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylamino]-4-oxo-4H-furo[2,3-c]chromene-6-carboxylate

Guidance literature:: Multi-step reaction with 9 steps

1: water; lithium hydroxide monohydrate / 1,4-dioxane / 5 h / 80 - 100 °C

2: dmap; dicyclohexyl-carbodiimide / tetrahydrofuran / 4 h / 20 °C

3: caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 3 h / 70 °C / Inert atmosphere

4: diethyl ether / 2 h / 20 °C

5: 2-methyl-but-2-ene; sodium chlorite; sodium dihydrogenphosphate / acetonitrile; water; tert-butyl alcohol / 4.5 h / 20 °C

6: dmap; dicyclohexyl-carbodiimide / tetrahydrofuran / 3 h / 20 °C

7: hydrogen / palladium 10% on activated carbon / ethyl acetate / 1.5 h / 20 °C

8: dichloromethane; pyridine / 6 h / 20 - 35 °C

9: tri tert-butylphosphoniumtetrafluoroborate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 1.25 h / 95 °C / Inert atmosphere

With dmap; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; lithium hydroxide monohydrate; water; hydrogen; caesium carbonate; dicyclohexyl-carbodiimide; tri tert-butylphosphoniumtetrafluoroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; pyridine; diethyl ether; dichloromethane; water; ethyl acetate; acetonitrile; tert-butyl alcohol;

Reference yield:

: 351003-45-7
2-bromo-4-fluorobenzene-1-sulfonyl chloride

: 1356112-77-0
tert-butyl 7-[2-((Z)-3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylamino]-4-oxo-4H-furo[2,3-c]chromene-6-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane; pyridine / 6 h / 20 - 35 °C

2: tri tert-butylphosphoniumtetrafluoroborate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 1.25 h / 95 °C / Inert atmosphere

With tri tert-butylphosphoniumtetrafluoroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; pyridine; dichloromethane;