7-[2-(Z)-(3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylamino]-4-oxo-4H-furo[2,3-c]chromene-6-carboxylic acid

Base Information

Chemical Name:7-[2-(Z)-(3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylamino]-4-oxo-4H-furo[2,3-c]chromene-6-carboxylic acid
CAS No.:1356111-13-1
Molecular Formula:C₂₅H₂₃FN₂O₇S
Molecular Weight:514.531
Hs Code.:

Synonyms:7-[2-(Z)-(3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylamino]-4-oxo-4H-furo[2,3-c]chromene-6-carboxylic acid

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Chemical Property of 7-[2-(Z)-(3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylamino]-4-oxo-4H-furo[2,3-c]chromene-6-carboxylic acid

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Technology Process of 7-[2-(Z)-(3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylamino]-4-oxo-4H-furo[2,3-c]chromene-6-carboxylic acid

There total 11 articles about 7-[2-(Z)-(3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylamino]-4-oxo-4H-furo[2,3-c]chromene-6-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1356112-77-0
tert-butyl 7-[2-((Z)-3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylamino]-4-oxo-4H-furo[2,3-c]chromene-6-carboxylate

: 1356111-13-1
7-[2-(Z)-(3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylamino]-4-oxo-4H-furo[2,3-c]chromene-6-carboxylic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;

Reference yield:

: 681247-11-0
methyl 6-amino-3-bromo-2-hydroxybenzoate

: 1356111-13-1
7-[2-(Z)-(3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylamino]-4-oxo-4H-furo[2,3-c]chromene-6-carboxylic acid

Guidance literature:: Multi-step reaction with 10 steps

1: water; lithium hydroxide monohydrate / 1,4-dioxane / 5 h / 80 - 100 °C

2: dmap; dicyclohexyl-carbodiimide / tetrahydrofuran / 4 h / 20 °C

3: caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 3 h / 70 °C / Inert atmosphere

4: diethyl ether / 2 h / 20 °C

5: 2-methyl-but-2-ene; sodium chlorite; sodium dihydrogenphosphate / acetonitrile; water; tert-butyl alcohol / 4.5 h / 20 °C

6: dmap; dicyclohexyl-carbodiimide / tetrahydrofuran / 3 h / 20 °C

7: hydrogen / palladium 10% on activated carbon / ethyl acetate / 1.5 h / 20 °C

8: dichloromethane; pyridine / 6 h / 20 - 35 °C

9: tri tert-butylphosphoniumtetrafluoroborate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 1.25 h / 95 °C / Inert atmosphere

10: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

With dmap; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; lithium hydroxide monohydrate; water; hydrogen; caesium carbonate; dicyclohexyl-carbodiimide; trifluoroacetic acid; tri tert-butylphosphoniumtetrafluoroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; pyridine; diethyl ether; dichloromethane; water; ethyl acetate; acetonitrile; tert-butyl alcohol;

Reference yield:

: 351003-45-7
2-bromo-4-fluorobenzene-1-sulfonyl chloride

: 1356111-13-1
7-[2-(Z)-(3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylamino]-4-oxo-4H-furo[2,3-c]chromene-6-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane; pyridine / 6 h / 20 - 35 °C

2: tri tert-butylphosphoniumtetrafluoroborate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 1.25 h / 95 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

With trifluoroacetic acid; tri tert-butylphosphoniumtetrafluoroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; pyridine; dichloromethane;