N-Boc-L-trans-4-phenylthioproline

Base Information

• Chemical Name: N-Boc-L-trans-4-phenylthioproline
• CAS No.: 146955-63-7
• Molecular Formula: C₁₆H₂₁NO₄S
• Molecular Weight: 323.413
• Mol file: 146955-63-7.mol

Synonyms:N-Boc-L-trans-4-phenylthioproline

Chemical Property of N-Boc-L-trans-4-phenylthioproline

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of N-Boc-L-trans-4-phenylthioproline

There total 2 articles about N-Boc-L-trans-4-phenylthioproline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(2S,4R)-1-tert-butyl 2-methyl 4-(phenylthio)pyrrolidine-1,2-dicarboxylate (146085-21-4) + cyclohexylamine (108-91-8,157973-60-9) + thiophenol (108-98-5) + O2-methyl O1-tert-butyl (2S,4S)-4-(p-tolylsulfonyloxy)pyrrolidine-1,2-dicarboxylic acid (146060-25-5) → N-Boc-L-trans-4-phenylthioproline (146955-63-7)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; methanol; water; acetonitrile;

Reference yield: 79.3%

(2S,4R)-1-tert-butyl 2-methyl 4-(phenylthio)pyrrolidine-1,2-dicarboxylate (146085-21-4) + thiophenol (108-98-5) + N-Boc-D-cis-4-(p-toluenesulfonyloxy)proline (153790-67-1) → N-Boc-L-trans-4-phenylthioproline (146955-63-7)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; methanol; water;

upstream raw materials:

(2S,4R)-1-tert-butyl 2-methyl 4-(phenylthio)pyrrolidine-1,2-dicarboxylate

cyclohexylamine

thiophenol

O2-methyl O1-tert-butyl (2S,4S)-4-(p-tolylsulfonyloxy)pyrrolidine-1,2-dicarboxylic acid