Benzyl 6-<<(tert-Butyl)dimethylsilyl>oxy>-3,6-dihydro-2H-1,2-oxazine-2-carboxylate

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Chemical Name:Benzyl 6-<<(tert-Butyl)dimethylsilyl>oxy>-3,6-dihydro-2H-1,2-oxazine-2-carboxylate
CAS No.:131507-55-6
Molecular Formula:C₁₈H₂₇NO₄Si
Molecular Weight:349.502
Hs Code.:

Synonyms:Benzyl 6-<<(tert-Butyl)dimethylsilyl>oxy>-3,6-dihydro-2H-1,2-oxazine-2-carboxylate

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Chemical Property of Benzyl 6-<<(tert-Butyl)dimethylsilyl>oxy>-3,6-dihydro-2H-1,2-oxazine-2-carboxylate

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Technology Process of Benzyl 6-<<(tert-Butyl)dimethylsilyl>oxy>-3,6-dihydro-2H-1,2-oxazine-2-carboxylate

There total 3 articles about Benzyl 6-<<(tert-Butyl)dimethylsilyl>oxy>-3,6-dihydro-2H-1,2-oxazine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 3426-71-9
Benzyl N-hydroxycarbamate

: 109987-02-2,88346-87-6
trans-1-(tert-butyldimethylsiloxy)butadiene

: 131507-60-3
Benzyl 3-<<(tert-Butyl)dimethylsilyl>oxy>-3,6-dihydro-2H-1,2-oxazine-2-carboxylate

: 131507-55-6
Benzyl 6-<<(tert-Butyl)dimethylsilyl>oxy>-3,6-dihydro-2H-1,2-oxazine-2-carboxylate

Guidance literature:: With molecular sieve; tetrapropylammonium periodate; In dichloromethane; at 0 ℃; for 1h; Yields of byproduct given;
DOI:10.1002/hlca.19910740806

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 131507-55-6
Benzyl 6-<<(tert-Butyl)dimethylsilyl>oxy>-3,6-dihydro-2H-1,2-oxazine-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / Et₃N, NaI / acetonitrile / 7 h / 50 °C

2: 68 percent / (Pr₄N)IO₄, molecular sieves / CH₂Cl₂ / 1 h / 0 °C

With molecular sieve; tetrapropylammonium periodate; triethylamine; sodium iodide; In dichloromethane; acetonitrile;
DOI:10.1002/hlca.19910740806

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 131507-55-6
Benzyl 6-<<(tert-Butyl)dimethylsilyl>oxy>-3,6-dihydro-2H-1,2-oxazine-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 73 percent / NH₂OH*HCl, K₂CO₃ / diethyl ether; H₂O / Ambient temperature

2: 68 percent / (Pr₄N)IO₄, molecular sieves / CH₂Cl₂ / 1 h / 0 °C

With molecular sieve; tetrapropylammonium periodate; hydroxylamine hydrochloride; potassium carbonate; In diethyl ether; dichloromethane; water;
DOI:10.1002/hlca.19910740806