6-Bromomethyl-2-p-chlorophenylchromone

Base Information

• Chemical Name: 6-Bromomethyl-2-p-chlorophenylchromone
• CAS No.: 60402-31-5
• Molecular Formula: C₁₆H₁₀BrClO₂
• Molecular Weight: 349.611
• Mol file: 60402-31-5.mol

Synonyms:6-Bromomethyl-2-p-chlorophenylchromone

Chemical Property of 6-Bromomethyl-2-p-chlorophenylchromone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-Bromomethyl-2-p-chlorophenylchromone

There total 7 articles about 6-Bromomethyl-2-p-chlorophenylchromone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(4-chlorophenyl)-6-methyl-4H-chromen-4-one (60402-30-4) → 6-Bromomethyl-2-p-chlorophenylchromone (60402-31-5)

Guidance literature:

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane;

Reference yield:

p-cresol (106-44-5) → 6-Bromomethyl-2-p-chlorophenylchromone (60402-31-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: pyridine

1.2: 130 °C

2.1: barium(II) hydroxide / ethanol

3.1: iodine / dimethyl sulfoxide / 3 h / 130 °C

4.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 8 h / Reflux

With pyridine; N-Bromosuccinimide; iodine; barium(II) hydroxide; dibenzoyl peroxide; In tetrachloromethane; ethanol; dimethyl sulfoxide;

DOI:10.1111/cbdd.12841

Reference yield:

5-methyl-2-hydroxyacetophenone (1450-72-2) → 6-Bromomethyl-2-p-chlorophenylchromone (60402-31-5)

Guidance literature:

Multi-step reaction with 3 steps

1: barium(II) hydroxide / ethanol

2: iodine / dimethyl sulfoxide / 3 h / 130 °C

3: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 8 h / Reflux

With N-Bromosuccinimide; iodine; barium(II) hydroxide; dibenzoyl peroxide; In tetrachloromethane; ethanol; dimethyl sulfoxide;

DOI:10.1111/cbdd.12841

upstream raw materials:

2-(4-chlorophenyl)-6-methyl-4H-chromen-4-one

4-chloro-benzoyl chloride

p-cresol

1-acetoxy-4-methylbenzene

Downstream raw materials:

2-(4-chlorophenyl)-6-((dimethylamino)methyl)-4H-chromen-4-one

2-(4-chlorophenyl)-6-((diethylamino)methyl)-4H-chromen-4-one

2-(4-chlorophenyl)-6-(piperidin-1-ylmethyl)-4H-chromen-4-one

2-(4-chlorophenyl)-6-(piperazin-1-ylmethyl)-4H-chromen-4-one

Refernces

• 1、 Wang, Xiao-Bing,Yang, Lei,Kong, Ling-Yi,Liu, Wei,Guo, Qing-Long. "Investigation on the substitution effects of the flavonoids as potent anticancer agents: A structure-activity relationships study". . p. 1833 - 1849,17. Retrieved 2020/07/30.