BOC-MET-GLY-OSU

Base Information

• Chemical Name: BOC-MET-GLY-OSU
• CAS No.: 23446-04-0
• Molecular Formula: C₁₆H₂₅N₃O₇S
• Molecular Weight: 403.456
• Mol file: 23446-04-0.mol

Synonyms:Succinimide,N-[[N-(N-carboxy-L-methionyl)glycyl]oxy]-, tert-butyl ester (8CI); Glycine,N-(N-carboxy-L-methionyl)-, N-tert-butyl ester, succinimido deriv. (8CI);Glycine, N-[N-[(1,1-dimethylethoxy)carbonyl]-L-methionyl]-,2,5-pyrrolidinedione deriv.

Chemical Property of BOC-MET-GLY-OSU

Chemical Property:

• PKA: 11.06±0.46(Predicted)
• PSA: 156.41000
• Density: 1.31±0.1 g/cm3(Predicted)
• LogP: 1.07590
• Storage Temp.: -15°C

Purity/Quality:

98% ^*data from raw suppliers

BOC-MET-GLY-OSU ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BOC-MET-GLY-OSU

There total 2 articles about BOC-MET-GLY-OSU which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + 2-((2S)-2-((tert-butoxycarbonyl)amino)-4-(methylthio)butanamido)acetic acid (23446-03-9) → Boc-Met-Gly-OSu (23446-04-0)

Guidance literature:

With dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; Ambient temperature;

DOI:10.1021/jm00391a017

Reference yield:

→ Boc-Met-Gly-OSu (23446-04-0)

Guidance literature:

Boc-Met-Gly (III), N-Hydroxysuccinimid, Dicyclohexylcarbodiimid, DMF, -10grad;

Reference yield:

Boc-Met-Gly-OSu (23446-04-0) → (S)-3-{(S)-2-[(S)-2-[2-((S)-2-Amino-4-methylsulfanyl-butyrylamino)-acetylamino]-3-(1H-indol-3-yl)-propionylamino]-hexanoylamino}-4-((S)-1-carbamoyl-2-phenyl-ethylamino)-butyric acid

Guidance literature:

Multi-step reaction with 2 steps

1: N,N-diisopropylethylamine / dimethylformamide / 2 h / Ambient temperature

2: TFA / 0.5 h

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In N,N-dimethyl-formamide;

DOI:10.1021/jm00391a017

upstream raw materials:

1-hydroxy-pyrrolidine-2,5-dione

2-((2S)-2-((tert-butoxycarbonyl)amino)-4-(methylthio)butanamido)acetic acid

Refernces