4-(2,5-difluorophenyl)-4-oxo-2E-butenoic acid

Base Information

Chemical Name:4-(2,5-difluorophenyl)-4-oxo-2E-butenoic acid
CAS No.:174415-29-3
Molecular Formula:C₁₀H₆F₂O₃
Molecular Weight:212.153
Hs Code.:

Synonyms:4-(2,5-difluorophenyl)-4-oxo-2E-butenoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(2,5-difluorophenyl)-4-oxo-2E-butenoic acid

Chemical Property:

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Technology Process of 4-(2,5-difluorophenyl)-4-oxo-2E-butenoic acid

There total 2 articles about 4-(2,5-difluorophenyl)-4-oxo-2E-butenoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 108-31-6
maleic anhydride

: 540-36-3
para-difluorobenzene

: 174415-29-3
4-(2,5-difluorophenyl)-4-oxo-2E-butenoic acid

Guidance literature:: With aluminium trichloride; at 100 ℃; for 1h;
DOI:10.1002/jhet.5570320605

Reference yield: 25.0%

: 1979-36-8
2',5'-difluoroacetophenone

: 298-12-4
Glyoxilic acid

: 174415-29-3
4-(2,5-difluorophenyl)-4-oxo-2E-butenoic acid

Guidance literature:: With hydrogenchloride; In water; acetic acid; for 18h; Reflux;
DOI:10.1111/cbdd.14005

Reference yield:

: 174415-29-3
4-(2,5-difluorophenyl)-4-oxo-2E-butenoic acid

: 157355-24-3
4-benzyloxy-6,9-bis<<2-(dimethylamino)ethyl>amino>benzisoquinoline-5,10-dione

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) ET₃N, methyl chloroformate / 1.) THF, -10 deg C, 2 h, 2.) THF, from -10 deg C to 20 deg C, 1 h

2: 53 percent / ethane-1,2-diamine / 4 h

3: 91 percent / fuming sulfuric acid (27-33percent SO₃) / 1 h / 127 °C

4: 39 percent / methanol; tetrahydrofuran / 12 h

5: 87 percent / pyridine / 74 h / Ambient temperature

With sulfuric acid; sulfur trioxide; triethylamine; methyl chloroformate; In tetrahydrofuran; pyridine; methanol; ethylenediamine;
DOI:10.1002/jhet.5570320605