tert-butyl 2-amino-4-(7-(((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)carbonylamino)heptyl)-1H-imidazole-1-carboxylate

Base Information

Chemical Name:tert-butyl 2-amino-4-(7-(((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)carbonylamino)heptyl)-1H-imidazole-1-carboxylate
CAS No.:1279724-30-9
Molecular Formula:C₂₆H₄₆N₄O₄
Molecular Weight:478.676
Hs Code.:

Synonyms:tert-butyl 2-amino-4-(7-(((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)carbonylamino)heptyl)-1H-imidazole-1-carboxylate

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Chemical Property of tert-butyl 2-amino-4-(7-(((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)carbonylamino)heptyl)-1H-imidazole-1-carboxylate

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Technology Process of tert-butyl 2-amino-4-(7-(((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)carbonylamino)heptyl)-1H-imidazole-1-carboxylate

There total 6 articles about tert-butyl 2-amino-4-(7-(((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)carbonylamino)heptyl)-1H-imidazole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1279724-25-2
tert-butyl 2-amino-4-(7-aminoheptyl)-1H-imidazole-1-carboxylate

: 14602-86-9,7635-53-2
(1R,2S,5R)-menthyl chloroformate

: 1279724-30-9
tert-butyl 2-amino-4-(7-(((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)carbonylamino)heptyl)-1H-imidazole-1-carboxylate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1016/j.bmcl.2010.12.057

Reference yield:

: 217180-77-3
8-azidooctanoyl chloride

: 1279724-30-9
tert-butyl 2-amino-4-(7-(((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)carbonylamino)heptyl)-1H-imidazole-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: dichloromethane / 1 h / 0 °C

2: N,N-dimethyl-formamide / 48 h

3: palladium 10% on activated carbon; hydrogen / methanol

4: triethylamine / dichloromethane / 0 - 20 °C

With palladium 10% on activated carbon; hydrogen; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2010.12.057

Reference yield:

: 1279724-16-1
9-azido-1-bromononan-2-one

: 1279724-30-9
tert-butyl 2-amino-4-(7-(((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)carbonylamino)heptyl)-1H-imidazole-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-dimethyl-formamide / 48 h

2: palladium 10% on activated carbon; hydrogen / methanol

3: triethylamine / dichloromethane / 0 - 20 °C

With palladium 10% on activated carbon; hydrogen; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2010.12.057