(E)-3-[(2S,4R,5R)-2-Phenyl-4-(2,2,2-trichloro-ethyl)-[1,3]dioxan-5-yloxy]-acrylic acid methyl ester

Base Information

Chemical Name:(E)-3-[(2S,4R,5R)-2-Phenyl-4-(2,2,2-trichloro-ethyl)-[1,3]dioxan-5-yloxy]-acrylic acid methyl ester
CAS No.:165545-39-1
Molecular Formula:C₁₆H₁₇Cl₃O₅
Molecular Weight:395.667
Hs Code.:

Synonyms:(E)-3-[(2S,4R,5R)-2-Phenyl-4-(2,2,2-trichloro-ethyl)-[1,3]dioxan-5-yloxy]-acrylic acid methyl ester

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Chemical Property of (E)-3-[(2S,4R,5R)-2-Phenyl-4-(2,2,2-trichloro-ethyl)-[1,3]dioxan-5-yloxy]-acrylic acid methyl ester

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Technology Process of (E)-3-[(2S,4R,5R)-2-Phenyl-4-(2,2,2-trichloro-ethyl)-[1,3]dioxan-5-yloxy]-acrylic acid methyl ester

There total 5 articles about (E)-3-[(2S,4R,5R)-2-Phenyl-4-(2,2,2-trichloro-ethyl)-[1,3]dioxan-5-yloxy]-acrylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 922-67-8
propynoic acid methyl ester

: 165545-37-9
(2S,4R,5R)-2-Phenyl-4-(2,2,2-trichloro-ethyl)-[1,3]dioxan-5-ol

: 165545-39-1
(E)-3-[(2S,4R,5R)-2-Phenyl-4-(2,2,2-trichloro-ethyl)-[1,3]dioxan-5-yloxy]-acrylic acid methyl ester

Guidance literature:: With 4-methyl-morpholine;
DOI:10.1021/ja00135a021

Reference yield:

: 1125-88-8
benzaldehyde dimethyl acetal

: 165545-39-1
(E)-3-[(2S,4R,5R)-2-Phenyl-4-(2,2,2-trichloro-ethyl)-[1,3]dioxan-5-yloxy]-acrylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 83 percent / acid

2: pyridine

3: 1.) LDA, 2.) HMPA / 2.) THF, ether, -110 deg C

4: 75 percent / H₂ / Pd/C

5: 100 percent / NMM

With 4-methyl-morpholine; pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; hydrogen; lithium diisopropyl amide; palladium on activated charcoal;
DOI:10.1021/ja00135a021

Reference yield:

: 165545-35-7
((2S,4R,5R)-5-Benzyloxy-2-phenyl-[1,3]dioxan-4-yl)-methanol

: 165545-39-1
(E)-3-[(2S,4R,5R)-2-Phenyl-4-(2,2,2-trichloro-ethyl)-[1,3]dioxan-5-yloxy]-acrylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine

2: 1.) LDA, 2.) HMPA / 2.) THF, ether, -110 deg C

3: 75 percent / H₂ / Pd/C

4: 100 percent / NMM

With 4-methyl-morpholine; pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; hydrogen; lithium diisopropyl amide; palladium on activated charcoal;
DOI:10.1021/ja00135a021