N-[(1S,9bS)-9b-(4-Bromo-phenyl)-7,8-dimethoxy-2-oxo-1,4,5,9b-tetrahydro-2H-azeto[2,1-a]isoquinolin-1-yl]-2-phenyl-acetamide

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Chemical Name:N-[(1S,9bS)-9b-(4-Bromo-phenyl)-7,8-dimethoxy-2-oxo-1,4,5,9b-tetrahydro-2H-azeto[2,1-a]isoquinolin-1-yl]-2-phenyl-acetamide
CAS No.:62333-92-0
Molecular Formula:C₂₇H₂₅BrN₂O₄
Molecular Weight:521.41
Hs Code.:

Synonyms:N-[(1S,9bS)-9b-(4-Bromo-phenyl)-7,8-dimethoxy-2-oxo-1,4,5,9b-tetrahydro-2H-azeto[2,1-a]isoquinolin-1-yl]-2-phenyl-acetamide

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Chemical Property of N-[(1S,9bS)-9b-(4-Bromo-phenyl)-7,8-dimethoxy-2-oxo-1,4,5,9b-tetrahydro-2H-azeto[2,1-a]isoquinolin-1-yl]-2-phenyl-acetamide

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Technology Process of N-[(1S,9bS)-9b-(4-Bromo-phenyl)-7,8-dimethoxy-2-oxo-1,4,5,9b-tetrahydro-2H-azeto[2,1-a]isoquinolin-1-yl]-2-phenyl-acetamide

There total 4 articles about N-[(1S,9bS)-9b-(4-Bromo-phenyl)-7,8-dimethoxy-2-oxo-1,4,5,9b-tetrahydro-2H-azeto[2,1-a]isoquinolin-1-yl]-2-phenyl-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 62333-81-7
(1R,9bR)-1-Amino-9b-(4-bromo-phenyl)-7,8-dimethoxy-1,4,5,9b-tetrahydro-azeto[2,1-a]isoquinolin-2-one

: 103-80-0
phenylacetyl chloride

: 62333-92-0
N-[(1S,9bS)-9b-(4-Bromo-phenyl)-7,8-dimethoxy-2-oxo-1,4,5,9b-tetrahydro-2H-azeto[2,1-a]isoquinolin-1-yl]-2-phenyl-acetamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 3h;
DOI:10.1016/S0040-4020(01)88885-2

Reference yield:

: 62333-71-5
6,7-dimethoxy-1-<(para-bromo)phenyl>-3,4-dihydroisoquinoline

: 62333-92-0
N-[(1S,9bS)-9b-(4-Bromo-phenyl)-7,8-dimethoxy-2-oxo-1,4,5,9b-tetrahydro-2H-azeto[2,1-a]isoquinolin-1-yl]-2-phenyl-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) Et₃N, ethyl chloroformate, 2.) Et₃N / 1.) ether, -25 deg C, 15 min, 2.) ether-CH₂Cl₂, 3 h at 0 deg C then 10-12 h at room temp

2: 2N HCl / acetone / 0.25 h / Ambient temperature

3: 55 percent / Et₃N / CH₂Cl₂ / 3 h / 0 °C

With hydrogenchloride; chloroformic acid ethyl ester; triethylamine; In dichloromethane; acetone;
DOI:10.1016/S0040-4020(01)88885-2

Reference yield:

: 80312-11-4
1,2-(4,5-dimethoxybenzo)-6-p-bromophenyl-7-(1'-methyl-2'-carbomethoxyvinylamino)octam

: 62333-92-0
N-[(1S,9bS)-9b-(4-Bromo-phenyl)-7,8-dimethoxy-2-oxo-1,4,5,9b-tetrahydro-2H-azeto[2,1-a]isoquinolin-1-yl]-2-phenyl-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 2N HCl / acetone / 0.25 h / Ambient temperature

2: 55 percent / Et₃N / CH₂Cl₂ / 3 h / 0 °C

With hydrogenchloride; triethylamine; In dichloromethane; acetone;
DOI:10.1016/S0040-4020(01)88885-2