(4-(2-phenyl-4-(pyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-5-yl)phenyl)methanol

Base Information

Chemical Name:(4-(2-phenyl-4-(pyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-5-yl)phenyl)methanol
CAS No.:1283092-13-6
Molecular Formula:C₂₇H₃₁N₃O₂Si
Molecular Weight:457.648
Hs Code.:

Synonyms:(4-(2-phenyl-4-(pyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-5-yl)phenyl)methanol

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Chemical Property of (4-(2-phenyl-4-(pyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-5-yl)phenyl)methanol

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Technology Process of (4-(2-phenyl-4-(pyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-5-yl)phenyl)methanol

There total 5 articles about (4-(2-phenyl-4-(pyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-5-yl)phenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1283092-12-5
methyl 4-(2-phenyl-4-(pyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-5-yl)benzoate

: 1283092-13-6
(4-(2-phenyl-4-(pyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-5-yl)phenyl)methanol

Guidance literature:: methyl 4-(2-phenyl-4-(pyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-5-yl)benzoate; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃;

With water; ammonium chloride; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 405554-88-3
4-(2-phenyl-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-yl)pyridine

: 1283092-13-6
(4-(2-phenyl-4-(pyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-5-yl)phenyl)methanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: bromine; sodium carbonate / dichloromethane; water / 0.67 h / 20 °C

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 16 h / 90 °C / Inert atmosphere

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C

3.2: 20 °C

With lithium aluminium tetrahydride; bromine; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water;

Reference yield:

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 1283092-13-6
(4-(2-phenyl-4-(pyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-5-yl)phenyl)methanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; oil / 0.5 h / 0 °C

1.2: 0 - 20 °C

2.1: bromine; sodium carbonate / dichloromethane; water / 0.67 h / 20 °C

3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 16 h / 90 °C / Inert atmosphere

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C

4.2: 20 °C

With lithium aluminium tetrahydride; bromine; sodium hydride; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide; oil;