(R)-tert-butyl 6-(2-((2-(3-amino-4-chlorophenyl)-2-hydroxyethyl)(tert-butoxycarbonyl)amino)ethoxy)-3-methylindazole-1-carboxylate

Base Information

Chemical Name:(R)-tert-butyl 6-(2-((2-(3-amino-4-chlorophenyl)-2-hydroxyethyl)(tert-butoxycarbonyl)amino)ethoxy)-3-methylindazole-1-carboxylate
CAS No.:1221179-43-6
Molecular Formula:C₂₈H₃₇ClN₄O₆
Molecular Weight:561.078
Hs Code.:

Synonyms:(R)-tert-butyl 6-(2-((2-(3-amino-4-chlorophenyl)-2-hydroxyethyl)(tert-butoxycarbonyl)amino)ethoxy)-3-methylindazole-1-carboxylate

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Chemical Property of (R)-tert-butyl 6-(2-((2-(3-amino-4-chlorophenyl)-2-hydroxyethyl)(tert-butoxycarbonyl)amino)ethoxy)-3-methylindazole-1-carboxylate

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Technology Process of (R)-tert-butyl 6-(2-((2-(3-amino-4-chlorophenyl)-2-hydroxyethyl)(tert-butoxycarbonyl)amino)ethoxy)-3-methylindazole-1-carboxylate

There total 9 articles about (R)-tert-butyl 6-(2-((2-(3-amino-4-chlorophenyl)-2-hydroxyethyl)(tert-butoxycarbonyl)amino)ethoxy)-3-methylindazole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1221179-42-5
(R)-tert-butyl 6-(2-((2-(3-amino-4-chlorophenyl)-2-hydroxyethyl)(benzyl)amino)ethoxy)-3-methylindazole-1-carboxylate

: 1221179-43-6
(R)-tert-butyl 6-(2-((2-(3-amino-4-chlorophenyl)-2-hydroxyethyl)(tert-butoxycarbonyl)amino)ethoxy)-3-methylindazole-1-carboxylate

Guidance literature:: (R)-tert-butyl 6-(2-((2-(3-amino-4-chlorophenyl)-2-hydroxyethyl)(benzyl)amino)ethoxy)-3-methylindazole-1-carboxylate; With hydrogenchloride; hydrogen; palladium 10% on activated carbon; In ethanol; at 20 ℃; for 0.666667h;

With triethylamine; In ethanol;

di-tert-butyl dicarbonate; In dichloromethane; at 20 ℃;

Reference yield:

: 201286-99-9
3-methyl-1H-indazol-6-ol

: 1221179-43-6
(R)-tert-butyl 6-(2-((2-(3-amino-4-chlorophenyl)-2-hydroxyethyl)(tert-butoxycarbonyl)amino)ethoxy)-3-methylindazole-1-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

2.1: triethylamine / dmap / dichloromethane / 20 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

4.1: triphenylphosphine; diamide / tetrahydrofuran / 20 °C

5.1: hydrogenchloride; hydrogen / 5%-palladium/activated carbon / water; methanol / 3 h / 20 °C

6.1: isopropyl alcohol / Reflux

7.1: hydrogen / CM-101 / tetrahydrofuran; methanol / 96 h / 20 °C

8.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / ethanol; water / 0.67 h / 20 °C

8.3: 20 °C

With 1H-imidazole; hydrogenchloride; diamide; tetrabutyl ammonium fluoride; hydrogen; triethylamine; triphenylphosphine; dmap; 5%-palladium/activated carbon; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 519158-44-2
1-benzyl-3-methyl-1H-indazol-6-ol

: 1221179-43-6
(R)-tert-butyl 6-(2-((2-(3-amino-4-chlorophenyl)-2-hydroxyethyl)(tert-butoxycarbonyl)amino)ethoxy)-3-methylindazole-1-carboxylate

Guidance literature:: Multi-step reaction with 9 steps

1.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / ethanol; water / 15 h / 60 °C / Inert atmosphere

2.1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

3.1: triethylamine / dmap / dichloromethane / 20 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

5.1: triphenylphosphine; diamide / tetrahydrofuran / 20 °C

6.1: hydrogenchloride; hydrogen / 5%-palladium/activated carbon / water; methanol / 3 h / 20 °C

7.1: isopropyl alcohol / Reflux

8.1: hydrogen / CM-101 / tetrahydrofuran; methanol / 96 h / 20 °C

9.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / ethanol; water / 0.67 h / 20 °C

9.3: 20 °C

With 1H-imidazole; hydrogenchloride; diamide; tetrabutyl ammonium fluoride; hydrogen; triethylamine; triphenylphosphine; dmap; 5%-palladium/activated carbon; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;