Technology Process of (R)-tert-butyl 6-(2-((2-(3-amino-4-chlorophenyl)-2-hydroxyethyl)(tert-butoxycarbonyl)amino)ethoxy)-3-methylindazole-1-carboxylate
There total 9 articles about (R)-tert-butyl 6-(2-((2-(3-amino-4-chlorophenyl)-2-hydroxyethyl)(tert-butoxycarbonyl)amino)ethoxy)-3-methylindazole-1-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(R)-tert-butyl 6-(2-((2-(3-amino-4-chlorophenyl)-2-hydroxyethyl)(benzyl)amino)ethoxy)-3-methylindazole-1-carboxylate;
With
hydrogenchloride; hydrogen;
palladium 10% on activated carbon;
In
ethanol;
at 20 ℃;
for 0.666667h;
With
triethylamine;
In
ethanol;
di-tert-butyl dicarbonate;
In
dichloromethane;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C
2.1: triethylamine / dmap / dichloromethane / 20 °C
3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C
4.1: triphenylphosphine; diamide / tetrahydrofuran / 20 °C
5.1: hydrogenchloride; hydrogen / 5%-palladium/activated carbon / water; methanol / 3 h / 20 °C
6.1: isopropyl alcohol / Reflux
7.1: hydrogen / CM-101 / tetrahydrofuran; methanol / 96 h / 20 °C
8.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / ethanol; water / 0.67 h / 20 °C
8.3: 20 °C
With
1H-imidazole; hydrogenchloride; diamide; tetrabutyl ammonium fluoride; hydrogen; triethylamine; triphenylphosphine;
dmap; 5%-palladium/activated carbon; palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / ethanol; water / 15 h / 60 °C / Inert atmosphere
2.1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C
3.1: triethylamine / dmap / dichloromethane / 20 °C
4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C
5.1: triphenylphosphine; diamide / tetrahydrofuran / 20 °C
6.1: hydrogenchloride; hydrogen / 5%-palladium/activated carbon / water; methanol / 3 h / 20 °C
7.1: isopropyl alcohol / Reflux
8.1: hydrogen / CM-101 / tetrahydrofuran; methanol / 96 h / 20 °C
9.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / ethanol; water / 0.67 h / 20 °C
9.3: 20 °C
With
1H-imidazole; hydrogenchloride; diamide; tetrabutyl ammonium fluoride; hydrogen; triethylamine; triphenylphosphine;
dmap; 5%-palladium/activated carbon; palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;