Multi-step reaction with 10 steps
1.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / ethanol; water / 15 h / 60 °C / Inert atmosphere
2.1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C
3.1: triethylamine / dmap / dichloromethane / 20 °C
4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C
5.1: triphenylphosphine; diamide / tetrahydrofuran / 20 °C
6.1: hydrogenchloride; hydrogen / 5%-palladium/activated carbon / water; methanol / 3 h / 20 °C
7.1: isopropyl alcohol / Reflux
8.1: hydrogen / CM-101 / tetrahydrofuran; methanol / 96 h / 20 °C
9.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / ethanol; water / 0.67 h / 20 °C
9.3: 20 °C
10.1: 1H-imidazole / N,N-dimethyl-formamide / 0.83 h / 20 °C
With
1H-imidazole; hydrogenchloride; diamide; tetrabutyl ammonium fluoride; hydrogen; triethylamine; triphenylphosphine;
dmap; 5%-palladium/activated carbon; palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;