1-[(5-chloro-1-phenylsulfonylindol-2-yl)sulfonyl]-3-(2-methylpropyl)piperazine

Base Information

Chemical Name:1-[(5-chloro-1-phenylsulfonylindol-2-yl)sulfonyl]-3-(2-methylpropyl)piperazine
CAS No.:259808-17-8
Molecular Formula:C₂₂H₂₆ClN₃O₄S₂
Molecular Weight:496.051
Hs Code.:

Synonyms:1-[(5-chloro-1-phenylsulfonylindol-2-yl)sulfonyl]-3-(2-methylpropyl)piperazine

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Chemical Property of 1-[(5-chloro-1-phenylsulfonylindol-2-yl)sulfonyl]-3-(2-methylpropyl)piperazine

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Technology Process of 1-[(5-chloro-1-phenylsulfonylindol-2-yl)sulfonyl]-3-(2-methylpropyl)piperazine

There total 7 articles about 1-[(5-chloro-1-phenylsulfonylindol-2-yl)sulfonyl]-3-(2-methylpropyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 249292-35-1
5-chloro-1-phenyl-sulfonylindole-2-sulfonyl chloride

: 859140-29-7
2-(2-methylpropyl)piperazine dihydrochloride

: 259808-17-8
1-[(5-chloro-1-phenylsulfonylindol-2-yl)sulfonyl]-3-(2-methylpropyl)piperazine

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 13h;
DOI:10.1016/j.bmc.2005.04.006

Reference yield:

: 249292-35-1
5-chloro-1-phenyl-sulfonylindole-2-sulfonyl chloride

: 859140-29-7
2-(2-methylpropyl)piperazine hydrochloride

: 259808-17-8
1-[(5-chloro-1-phenylsulfonylindol-2-yl)sulfonyl]-3-(2-methylpropyl)piperazine

Guidance literature:: With triethylamine; In dichloromethane;

Reference yield:

: 72351-59-8
ethyl 1,4-dibenzylpiperazin-2-carboxylate

: 259808-17-8
1-[(5-chloro-1-phenylsulfonylindol-2-yl)sulfonyl]-3-(2-methylpropyl)piperazine

Guidance literature:: Multi-step reaction with 4 steps

1: diisobutylaluminum hydride / CH₂Cl₂; hexane / 2.5 h / -78 °C

2: 6.0 g / n-butyllithium / tetrahydrofuran; hexane / -78 - 20 °C

3: 85 percent / hydrogen; hydrochloric acid / palladium hydroxide / ethanol; H₂O / 2 h / 20 °C

4: 78 percent / triethylamine / CH₂Cl₂ / 13 h / 20 °C

With hydrogenchloride; n-butyllithium; hydrogen; diisobutylaluminium hydride; triethylamine; palladium dihydroxide; In tetrahydrofuran; ethanol; hexane; dichloromethane; water; 2: Wittig reaction;
DOI:10.1016/j.bmc.2005.04.006