1-{(2R,5R)-4-[(2-{[(1,1-dimethylethyl)dimethylsilyl]oxy}ethyl)sulfonyl]-2,5-dihydro-5-[(triphenylmethoxy)methyl]furan-2-yl}pyrimidine-2,4(1H,3H)-dione

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Chemical Name:1-{(2R,5R)-4-[(2-{[(1,1-dimethylethyl)dimethylsilyl]oxy}ethyl)sulfonyl]-2,5-dihydro-5-[(triphenylmethoxy)methyl]furan-2-yl}pyrimidine-2,4(1H,3H)-dione
CAS No.:202260-01-3
Molecular Formula:C₃₆H₄₂N₂O₇SSi
Molecular Weight:674.89
Hs Code.:

Synonyms:1-{(2R,5R)-4-[(2-{[(1,1-dimethylethyl)dimethylsilyl]oxy}ethyl)sulfonyl]-2,5-dihydro-5-[(triphenylmethoxy)methyl]furan-2-yl}pyrimidine-2,4(1H,3H)-dione

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Chemical Property of 1-{(2R,5R)-4-[(2-{[(1,1-dimethylethyl)dimethylsilyl]oxy}ethyl)sulfonyl]-2,5-dihydro-5-[(triphenylmethoxy)methyl]furan-2-yl}pyrimidine-2,4(1H,3H)-dione

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Technology Process of 1-{(2R,5R)-4-[(2-{[(1,1-dimethylethyl)dimethylsilyl]oxy}ethyl)sulfonyl]-2,5-dihydro-5-[(triphenylmethoxy)methyl]furan-2-yl}pyrimidine-2,4(1H,3H)-dione

There total 7 articles about 1-{(2R,5R)-4-[(2-{[(1,1-dimethylethyl)dimethylsilyl]oxy}ethyl)sulfonyl]-2,5-dihydro-5-[(triphenylmethoxy)methyl]furan-2-yl}pyrimidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: Methanesulfonic acid (2R,3R,4R,5R)-4-[2-(tert-butyl-dimethyl-silanyloxy)-ethanesulfonyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-5-trityloxymethyl-tetrahydro-furan-3-yl ester

: 202260-01-3
1-{(2R,5R)-4-[(2-{[(1,1-dimethylethyl)dimethylsilyl]oxy}ethyl)sulfonyl]-2,5-dihydro-5-[(triphenylmethoxy)methyl]furan-2-yl}pyrimidine-2,4(1H,3H)-dione

Guidance literature:: With water; In pyridine; at 40 - 50 ℃; for 2h;
DOI:10.1002/hlca.200790199

Reference yield:

: 96253-10-0
1-[2,3-epoxy-5-O-(triphenylmethyl)-β-D-lyxofuranosyl]pyrimidine-2,4(1H,3H)-dione

: 202260-01-3
1-{(2R,5R)-4-[(2-{[(1,1-dimethylethyl)dimethylsilyl]oxy}ethyl)sulfonyl]-2,5-dihydro-5-[(triphenylmethoxy)methyl]furan-2-yl}pyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 5 steps

2: 96 percent / NaOH / ethanol; H₂O / 2 h / Ambient temperature

3: 93 percent / imidazole / dimethylformamide / 8 h / Ambient temperature

4: 90 percent / magnesium monoperphthalate / methanol / Ambient temperature

5: 1.) mesyl chloride, pyridine / 1.) 4 deg C, overnight, 2.) water, 40 deg C, 1.5 h

With pyridine; 1H-imidazole; sodium hydroxide; magnesium monoperoxyphthalate hexahydrate; methanesulfonyl chloride; In methanol; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jo9705576

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 202260-01-3
1-{(2R,5R)-4-[(2-{[(1,1-dimethylethyl)dimethylsilyl]oxy}ethyl)sulfonyl]-2,5-dihydro-5-[(triphenylmethoxy)methyl]furan-2-yl}pyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / imidazole / dimethylformamide / 8 h / Ambient temperature

2: 90 percent / magnesium monoperphthalate / methanol / Ambient temperature

3: 1.) mesyl chloride, pyridine / 1.) 4 deg C, overnight, 2.) water, 40 deg C, 1.5 h

With pyridine; 1H-imidazole; magnesium monoperoxyphthalate hexahydrate; methanesulfonyl chloride; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jo9705576