((R)-3-(4-fluorophenyl)pyrrolidin-1-yl)((2S,4R)-4-(fluorophenyl)pyrrolidin-2-yl)methanone hydrochloride

Base Information

Chemical Name:((R)-3-(4-fluorophenyl)pyrrolidin-1-yl)((2S,4R)-4-(fluorophenyl)pyrrolidin-2-yl)methanone hydrochloride
CAS No.:1201986-55-1
Molecular Formula:C₂₁H₂₂F₂N₂O*ClH
Molecular Weight:392.876
Hs Code.:

Synonyms:((R)-3-(4-fluorophenyl)pyrrolidin-1-yl)((2S,4R)-4-(fluorophenyl)pyrrolidin-2-yl)methanone hydrochloride

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Chemical Property of ((R)-3-(4-fluorophenyl)pyrrolidin-1-yl)((2S,4R)-4-(fluorophenyl)pyrrolidin-2-yl)methanone hydrochloride

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Technology Process of ((R)-3-(4-fluorophenyl)pyrrolidin-1-yl)((2S,4R)-4-(fluorophenyl)pyrrolidin-2-yl)methanone hydrochloride

There total 10 articles about ((R)-3-(4-fluorophenyl)pyrrolidin-1-yl)((2S,4R)-4-(fluorophenyl)pyrrolidin-2-yl)methanone hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1201987-30-5
(2S,4R)-tert-butyl 4-(4-fluorophenyl)-2-((R)-3-(4-fluorophenyl)pyrrolidine-1-carbonyl)pyrrolidine-1-carboxylate

: 1201986-55-1
((R)-3-(4-fluorophenyl)pyrrolidin-1-yl)((2S,4R)-4-(fluorophenyl)pyrrolidin-2-yl)methanone hydrochloride

Guidance literature:: With hydrogenchloride; water; In 1,4-dioxane; at 0 - 25 ℃;

Reference yield:

: 166410-05-5
tert-butyl N^α-Boc-4-keto-L-prolinate

: 1201986-55-1
((R)-3-(4-fluorophenyl)pyrrolidin-1-yl)((2S,4R)-4-(fluorophenyl)pyrrolidin-2-yl)methanone hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrahydrofuran / -78 - 25 °C

1.2: 18 - 25 °C

2.1: trifluoroacetic acid / dichloromethane / 0 - 25 °C

3.1: hydrogen / palladium over charcoal / methanol / 18 - 25 °C

4.1: sodium hydrogencarbonate / 1,4-dioxane; water / 0 - 25 °C

4.2: 18 - 25 °C / pH ~ 6

5.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane; N,N-dimethyl-formamide / 0 - 25 °C

6.1: hydrogenchloride; water / 1,4-dioxane / 0 - 25 °C

With hydrogenchloride; water; hydrogen; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; palladium over charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1201986-74-4
(S)-4-(4-fluorophenyl)-2,5-dihydro-1H-pyrrole-2-carboxylic acid

: 1201986-55-1
((R)-3-(4-fluorophenyl)pyrrolidin-1-yl)((2S,4R)-4-(fluorophenyl)pyrrolidin-2-yl)methanone hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / palladium over charcoal / methanol / 18 - 25 °C

2.1: sodium hydrogencarbonate / 1,4-dioxane; water / 0 - 25 °C

2.2: 18 - 25 °C / pH ~ 6

3.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane; N,N-dimethyl-formamide / 0 - 25 °C

4.1: hydrogenchloride; water / 1,4-dioxane / 0 - 25 °C

With hydrogenchloride; water; hydrogen; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; HATU; palladium over charcoal; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;