diethyl [4-(3'-iso-propyl-4'-methanesulfonylaminobenzyl)-3,5-dimethylphenoxy]methylphosphonate

Base Information

• Chemical Name: diethyl [4-(3'-iso-propyl-4'-methanesulfonylaminobenzyl)-3,5-dimethylphenoxy]methylphosphonate
• CAS No.: 852947-59-2
• Molecular Formula: C₂₄H₃₆NO₆PS
• Molecular Weight: 497.593
• Mol file: 852947-59-2.mol

Synonyms:diethyl [4-(3'-iso-propyl-4'-methanesulfonylaminobenzyl)-3,5-dimethylphenoxy]methylphosphonate

Chemical Property of diethyl [4-(3'-iso-propyl-4'-methanesulfonylaminobenzyl)-3,5-dimethylphenoxy]methylphosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl [4-(3'-iso-propyl-4'-methanesulfonylaminobenzyl)-3,5-dimethylphenoxy]methylphosphonate

There total 2 articles about diethyl [4-(3'-iso-propyl-4'-methanesulfonylaminobenzyl)-3,5-dimethylphenoxy]methylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

diethyl [4-(4'-amino-3'-iso-propylbenzyl)-3,5-dimethylphenoxy]methylphosphonate (852947-58-1) + methanesulfonyl chloride (124-63-0) → diethyl [4-(3'-iso-propyl-4'-methanesulfonylaminobenzyl)-3,5-dimethylphenoxy]methylphosphonate (852947-59-2)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃;

Reference yield:

4-(4'-amino-3'-iso-propylbenzyl)-3,5-dimethylphenol (852947-57-0) + (diethoxyphosphinyl)methyl trifluoromethanesulfonate (106938-62-9) → diethyl [4-(3'-iso-propyl-4'-methanesulfonylaminobenzyl)-3,5-dimethylphenoxy]methylphosphonate (852947-59-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 20 °C

2: pyridine / dichloromethane / 20 °C

With pyridine; sodium hydride; In dichloromethane; N,N-dimethyl-formamide;

Reference yield: 55.0%

diethyl [4-(3'-iso-propyl-4'-methanesulfonylaminobenzyl)-3,5-dimethylphenoxy]methylphosphonate (852947-59-2) → [4-(3'-iso-propyl-4'-methanesulfonylaminobemzyl)-3,5-dirnethylphenoxy]methylphosphonic acid (852947-55-8)

Guidance literature:

With trimethylsilyl bromide; 1,1,1,3,3,3-hexamethyl-disilazane; In dichloromethane; at 20 ℃;

upstream raw materials:

diethyl [4-(4'-amino-3'-iso-propylbenzyl)-3,5-dimethylphenoxy]methylphosphonate

methanesulfonyl chloride

4-(4'-amino-3'-iso-propylbenzyl)-3,5-dimethylphenol

(diethoxyphosphinyl)methyl trifluoromethanesulfonate

Downstream raw materials:

[4-(3'-iso-propyl-4'-methanesulfonylaminobemzyl)-3,5-dirnethylphenoxy]methylphosphonic acid