trans-4-(4-indazol-1-yl-pyrimidin-2-ylamino)-cyclo-hexanecarboxylic acid (3-hydroxy-butyl)amide

Base Information

Chemical Name:trans-4-(4-indazol-1-yl-pyrimidin-2-ylamino)-cyclo-hexanecarboxylic acid (3-hydroxy-butyl)amide
CAS No.:1032452-12-2
Molecular Formula:C₂₂H₂₈N₆O₂
Molecular Weight:408.503
Hs Code.:

Synonyms:trans-4-(4-indazol-1-yl-pyrimidin-2-ylamino)-cyclo-hexanecarboxylic acid (3-hydroxy-butyl)amide

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Chemical Property of trans-4-(4-indazol-1-yl-pyrimidin-2-ylamino)-cyclo-hexanecarboxylic acid (3-hydroxy-butyl)amide

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Technology Process of trans-4-(4-indazol-1-yl-pyrimidin-2-ylamino)-cyclo-hexanecarboxylic acid (3-hydroxy-butyl)amide

There total 7 articles about trans-4-(4-indazol-1-yl-pyrimidin-2-ylamino)-cyclo-hexanecarboxylic acid (3-hydroxy-butyl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1032452-70-2
trans-4-(4-indazol-1-ylpyrimidin-2-ylamino)-cyclohexanecarboxylic acid

: 114963-62-1,127912-49-6,39884-48-5
4-amino-butan-2-ol

: 1032452-12-2
trans-4-(4-indazol-1-yl-pyrimidin-2-ylamino)-cyclo-hexanecarboxylic acid (3-hydroxy-butyl)amide

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 271-44-3
benzimidazole

: 1032452-12-2
trans-4-(4-indazol-1-yl-pyrimidin-2-ylamino)-cyclo-hexanecarboxylic acid (3-hydroxy-butyl)amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 20 °C

1.2: 2.5 h / 20 - 70 °C

2.1: 3-chloro-benzenecarboperoxoic acid / chloroform / Cooling with acetone-dry ice

3.1: triethylamine / tetrahydrofuran / 60 °C

4.1: sodium hydroxide; water / tetrahydrofuran; methanol

4.2: pH 3

5.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

With sodium hydroxide; water; sodium hydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; chloroform; N,N-dimethyl-formamide;

Reference yield:

: 1032452-66-6
1-(2-methanesulfonyl-pyrimidin-4-yl)-1H-indazole

: 1032452-12-2
trans-4-(4-indazol-1-yl-pyrimidin-2-ylamino)-cyclo-hexanecarboxylic acid (3-hydroxy-butyl)amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / tetrahydrofuran / 60 °C

2.1: sodium hydroxide; water / tetrahydrofuran; methanol

2.2: pH 3

3.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

With sodium hydroxide; water; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol;