3-chloro-N-(2,4-difluoro-3-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-ylamino)phenyl)-2-methylbenzenesulfonamide

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Chemical Name:3-chloro-N-(2,4-difluoro-3-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-ylamino)phenyl)-2-methylbenzenesulfonamide
CAS No.:1380228-91-0
Molecular Formula:C₂₈H₂₄ClF₂N₇O₃S
Molecular Weight:612.059
Hs Code.:

Synonyms:3-chloro-N-(2,4-difluoro-3-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-ylamino)phenyl)-2-methylbenzenesulfonamide

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Chemical Property of 3-chloro-N-(2,4-difluoro-3-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-ylamino)phenyl)-2-methylbenzenesulfonamide

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Technology Process of 3-chloro-N-(2,4-difluoro-3-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-ylamino)phenyl)-2-methylbenzenesulfonamide

There total 16 articles about 3-chloro-N-(2,4-difluoro-3-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-ylamino)phenyl)-2-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1380228-73-8
2,6-difluoro-N₁-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-yl)benzene-1,3-diamine

: 80563-86-6
3-chloro-2-methylbenzenesulfonyl chloride

: 1380228-91-0
3-chloro-N-(2,4-difluoro-3-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-ylamino)phenyl)-2-methylbenzenesulfonamide

Guidance literature:: With pyridine; In dichloromethane; at 50 ℃; for 2h;

Reference yield:

: 1093101-52-0
6-(2-fluoropyridin-3-yl)-9-(tetrahydro-2-hydro-pyran-2-yl)-9H-purine

: C₁₃H₁₁ClF₂N₂O₂S

: 1380228-91-0
3-chloro-N-(2,4-difluoro-3-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-ylamino)phenyl)-2-methylbenzenesulfonamide

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at 0 ℃; for 1h;
DOI:10.1002/bkcs.10917

Reference yield:

: 385-00-2
2,6-difluorobenzoic acid

: 1380228-91-0
3-chloro-N-(2,4-difluoro-3-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-ylamino)phenyl)-2-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: sulfuric acid; potassium nitrate / 24 h / 0 - 20 °C

2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 18 h / 20 °C

3.1: sodium azide / dichloromethane / 0.5 h / 20 °C

3.2: 3 h / Reflux

4.1: palladium on activated charcoal; hydrogen / methanol / 15 h

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 5 h / 20 °C

6.1: hydrogenchloride / ethyl acetate; 1,4-dioxane / 5 h / 20 °C

7.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 0 - 20 °C

8.1: palladium on activated charcoal; hydrogen / methanol / 1 h

9.1: pyridine / dichloromethane / 2 h / 50 °C

With pyridine; hydrogenchloride; sodium azide; oxalyl dichloride; sulfuric acid; palladium on activated charcoal; hydrogen; potassium nitrate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; ethyl acetate;