(1'R,2'S)-2-<2-(N-benzyl-N-tert-butoxycarbonylamino)-1-hydroxy-3-phenylpropyl>-1,3-thiazole

Base Information

Chemical Name:(1'R,2'S)-2-<2-(N-benzyl-N-tert-butoxycarbonylamino)-1-hydroxy-3-phenylpropyl>-1,3-thiazole
CAS No.:145655-01-2
Molecular Formula:C₂₄H₂₈N₂O₃S
Molecular Weight:424.564
Hs Code.:

Synonyms:(1'R,2'S)-2-<2-(N-benzyl-N-tert-butoxycarbonylamino)-1-hydroxy-3-phenylpropyl>-1,3-thiazole

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Chemical Property of (1'R,2'S)-2-<2-(N-benzyl-N-tert-butoxycarbonylamino)-1-hydroxy-3-phenylpropyl>-1,3-thiazole

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Technology Process of (1'R,2'S)-2-<2-(N-benzyl-N-tert-butoxycarbonylamino)-1-hydroxy-3-phenylpropyl>-1,3-thiazole

There total 11 articles about (1'R,2'S)-2-<2-(N-benzyl-N-tert-butoxycarbonylamino)-1-hydroxy-3-phenylpropyl>-1,3-thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 145655-00-1
2-(N-benzyl-N-tert-butoxycarbonylphenylalanyl)-1,3-thiazole

: 145655-01-2
(1'R,2'S)-2-<2-(N-benzyl-N-tert-butoxycarbonylamino)-1-hydroxy-3-phenylpropyl>-1,3-thiazole

Guidance literature:: With sodium tetrahydroborate; In methanol; at -80 ℃; for 0.5h;
DOI:10.1016/S0040-4039(00)60888-2 DOI:10.1055/s-1993-26021

Reference yield:

: 145654-99-5
(S)-2-(benzyl-tert-butoxycarbonyl-amino)-3-phenyl-propionic acid methyl ester

: 145655-01-2
(1'R,2'S)-2-<2-(N-benzyl-N-tert-butoxycarbonylamino)-1-hydroxy-3-phenylpropyl>-1,3-thiazole

Guidance literature:: Multi-step reaction with 2 steps

1: DIBALH / CH₂Cl₂; toluene / 2 h / -78 °C

2: 2.) Bu₄NF*3H₂O / 1.) CH₂Cl₂, -20 deg C, 48 h, 2.) THF, r.t. 1 h

With tetrabutyl ammonium fluoride; diisobutylaluminium hydride; In dichloromethane; toluene;
DOI:10.1021/jo00129a057

Reference yield:

: 66399-75-5,84028-90-0
(S)-2-benzylamino-3-phenyl-propionic acid methyl ester

: 145655-01-2
(1'R,2'S)-2-<2-(N-benzyl-N-tert-butoxycarbonylamino)-1-hydroxy-3-phenylpropyl>-1,3-thiazole

Guidance literature:: Multi-step reaction with 3 steps

1: NaBH₄ / dioxane / 18 h / Ambient temperature

2: 91 percent / BuLi / hexane; diethyl ether / 4 h / -65 °C

3: 95 percent / NaBH₄ / methanol / 0.5 h / -80 °C

With sodium tetrahydroborate; n-butyllithium; In 1,4-dioxane; methanol; diethyl ether; hexane;
DOI:10.1055/s-1993-26021