3-[4-(4-chloro)phenyl-6-(morpholin-4-yl)-3(2H)-pyridazinon-2-yl]propanenitrile

Base Information

Chemical Name:3-[4-(4-chloro)phenyl-6-(morpholin-4-yl)-3(2H)-pyridazinon-2-yl]propanenitrile
CAS No.:902456-41-1
Molecular Formula:C₁₇H₁₇ClN₄O₂
Molecular Weight:344.801
Hs Code.:

Synonyms:3-[4-(4-chloro)phenyl-6-(morpholin-4-yl)-3(2H)-pyridazinon-2-yl]propanenitrile

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Chemical Property of 3-[4-(4-chloro)phenyl-6-(morpholin-4-yl)-3(2H)-pyridazinon-2-yl]propanenitrile

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Technology Process of 3-[4-(4-chloro)phenyl-6-(morpholin-4-yl)-3(2H)-pyridazinon-2-yl]propanenitrile

There total 3 articles about 3-[4-(4-chloro)phenyl-6-(morpholin-4-yl)-3(2H)-pyridazinon-2-yl]propanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 902456-35-3
4-(4-chloro)phenyl-6-(morpholin-4-yl)-3(2H)-pyridazinone

: 107-13-1,25014-41-9
acrylonitrile

: 902456-41-1
3-[4-(4-chloro)phenyl-6-(morpholin-4-yl)-3(2H)-pyridazinon-2-yl]propanenitrile

Guidance literature:: With potassium carbonate; In ethyl acetate; for 12h; Heating;

Reference yield:

: 902456-33-1
3-chloro-4-(4-chloro)phenyl-6-(morpholin-4-yl)-pyridazine

: 902456-41-1
3-[4-(4-chloro)phenyl-6-(morpholin-4-yl)-3(2H)-pyridazinon-2-yl]propanenitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / potassium acetate / acetic acid / 10 h / Heating

2: 97 percent / K₂CO₃ / ethyl acetate / 12 h / Heating

With potassium acetate; potassium carbonate; In acetic acid; ethyl acetate; 2: Michael addition;

Reference yield:

: 41373-97-1
3,6-dichloro-4-(4-chloro-phenyl)-pyridazine

: 902456-41-1
3-[4-(4-chloro)phenyl-6-(morpholin-4-yl)-3(2H)-pyridazinon-2-yl]propanenitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / Et₃N / propan-2-ol / 12 h / Heating

2: 96 percent / potassium acetate / acetic acid / 10 h / Heating

3: 97 percent / K₂CO₃ / ethyl acetate / 12 h / Heating

With potassium acetate; potassium carbonate; triethylamine; In acetic acid; ethyl acetate; isopropyl alcohol; 3: Michael addition;