1-benzyloxycarbonylmethyl-1,2,3,4-tetrahydro-2-(2,2,2-trichloroethoxycarbonyl)-β-carboline

Base Information

Chemical Name:1-benzyloxycarbonylmethyl-1,2,3,4-tetrahydro-2-(2,2,2-trichloroethoxycarbonyl)-β-carboline
CAS No.:591225-67-1
Molecular Formula:C₂₃H₂₁Cl₃N₂O₄
Molecular Weight:495.79
Hs Code.:

Synonyms:1-benzyloxycarbonylmethyl-1,2,3,4-tetrahydro-2-(2,2,2-trichloroethoxycarbonyl)-β-carboline

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Chemical Property of 1-benzyloxycarbonylmethyl-1,2,3,4-tetrahydro-2-(2,2,2-trichloroethoxycarbonyl)-β-carboline

Chemical Property:

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Technology Process of 1-benzyloxycarbonylmethyl-1,2,3,4-tetrahydro-2-(2,2,2-trichloroethoxycarbonyl)-β-carboline

There total 6 articles about 1-benzyloxycarbonylmethyl-1,2,3,4-tetrahydro-2-(2,2,2-trichloroethoxycarbonyl)-β-carboline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 474433-52-8
1-benzyloxycarbonylmethyl-1,2-dihydro-2-(2,2,2-trichloroethoxycarbonyl)-β-carboline

: 591225-67-1
1-benzyloxycarbonylmethyl-1,2,3,4-tetrahydro-2-(2,2,2-trichloroethoxycarbonyl)-β-carboline

Guidance literature:: With triethylsilane; trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.25h;
DOI:10.1016/S0040-4020(03)00420-4

Reference yield:

: 244-63-3
betacarboline

: 591225-67-1
1-benzyloxycarbonylmethyl-1,2,3,4-tetrahydro-2-(2,2,2-trichloroethoxycarbonyl)-β-carboline

Guidance literature:: Multi-step reaction with 3 steps

1.1: 95 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 4 h / 20 °C

2.1: CH₂Cl₂ / 12 h / -40 °C

2.2: NaOH / tetrahydrofuran; H₂O / 1 h / 20 °C

3.1: 87 percent / triethylsilane; trifluoroacetic acid / CH₂Cl₂ / 0.25 h / 20 °C

With triethylsilane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/S0040-4020(03)00420-4

Reference yield:

: 474433-42-6
9-[N-(anthracen-9-ylmethyl)-(S)-pyroglutamyl]-β-carboline

: 591225-67-1
1-benzyloxycarbonylmethyl-1,2,3,4-tetrahydro-2-(2,2,2-trichloroethoxycarbonyl)-β-carboline

Guidance literature:: Multi-step reaction with 2 steps

1.1: CH₂Cl₂ / 12 h / -40 °C

1.2: NaOH / tetrahydrofuran; H₂O / 1 h / 20 °C

2.1: 87 percent / triethylsilane; trifluoroacetic acid / CH₂Cl₂ / 0.25 h / 20 °C

With triethylsilane; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/S0040-4020(03)00420-4