1-benzyloxycarbonylmethyl-1,2-dihydro-2-(2,2,2-trichloroethoxycarbonyl)-β-carboline

Base Information

Chemical Name:1-benzyloxycarbonylmethyl-1,2-dihydro-2-(2,2,2-trichloroethoxycarbonyl)-β-carboline
CAS No.:474433-52-8
Molecular Formula:C₂₃H₁₉Cl₃N₂O₄
Molecular Weight:493.774
Hs Code.:

Synonyms:1-benzyloxycarbonylmethyl-1,2-dihydro-2-(2,2,2-trichloroethoxycarbonyl)-β-carboline

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Chemical Property of 1-benzyloxycarbonylmethyl-1,2-dihydro-2-(2,2,2-trichloroethoxycarbonyl)-β-carboline

Chemical Property:

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Technology Process of 1-benzyloxycarbonylmethyl-1,2-dihydro-2-(2,2,2-trichloroethoxycarbonyl)-β-carboline

There total 5 articles about 1-benzyloxycarbonylmethyl-1,2-dihydro-2-(2,2,2-trichloroethoxycarbonyl)-β-carboline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 244-63-3
betacarboline

: 474433-52-8
1-benzyloxycarbonylmethyl-1,2-dihydro-2-(2,2,2-trichloroethoxycarbonyl)-β-carboline

Guidance literature:: Multi-step reaction with 2 steps

1.1: 95 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 4 h / 20 °C

2.1: CH₂Cl₂ / 12 h / -40 °C

2.2: NaOH / tetrahydrofuran; H₂O / 1 h / 20 °C

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1016/S0040-4020(03)00420-4

Reference yield:

: 81171-44-0
1-benzyloxy-1-(trimethylsilyloxy)ethylene

: 591226-05-0
9-[N-(p-nitrobenzoyl)-(S)-pyroglutamyl]-β-carboline

: 17341-93-4
2,2,2-Trichloroethyl chloroformate

: 474433-52-8
1-benzyloxycarbonylmethyl-1,2-dihydro-2-(2,2,2-trichloroethoxycarbonyl)-β-carboline

: 1-benzyloxycarbonylmethyl-1,2-dihydro-2-(2,2,2-trichloroethoxycarbonyl)-β-carboline

Guidance literature:: 1-benzyloxy-1-(trimethylsilyloxy)ethylene; 9-[N-(p-nitrobenzoyl)-(S)-pyroglutamyl]-β-carboline; 2,2,2-Trichloroethyl chloroformate; In dichloromethane; at -78 ℃; for 40h;

With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 1h; Title compound not separated from byproducts;
DOI:10.1016/S0040-4020(03)00420-4

Reference yield:

: 81171-44-0
1-benzyloxy-1-(trimethylsilyloxy)ethylene

: 474433-42-6
9-[N-(anthracen-9-ylmethyl)-(S)-pyroglutamyl]-β-carboline

: 17341-93-4
2,2,2-Trichloroethyl chloroformate

: 474433-52-8
1-benzyloxycarbonylmethyl-1,2-dihydro-2-(2,2,2-trichloroethoxycarbonyl)-β-carboline

: 1-benzyloxycarbonylmethyl-1,2-dihydro-2-(2,2,2-trichloroethoxycarbonyl)-β-carboline

Guidance literature:: 1-benzyloxy-1-(trimethylsilyloxy)ethylene; 9-[N-(anthracen-9-ylmethyl)-(S)-pyroglutamyl]-β-carboline; 2,2,2-Trichloroethyl chloroformate; In dichloromethane; at -40 ℃; for 12h;

With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 1h; Title compound not separated from byproducts;
DOI:10.1016/S0040-4020(03)00420-4