(R)-ethyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-(1H-indol-3-yl)propanamido)-3-((1-(3-(5-(dimethylamino)naphthalene-1-sulfonamido)propyl)-1H-1,2,3-triazol-4-yl)thio)propanoate

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Chemical Name:(R)-ethyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-(1H-indol-3-yl)propanamido)-3-((1-(3-(5-(dimethylamino)naphthalene-1-sulfonamido)propyl)-1H-1,2,3-triazol-4-yl)thio)propanoate
CAS No.:1443746-73-3
Molecular Formula:C₄₁H₄₆N₈O₇S₂
Molecular Weight:826.998
Hs Code.:

(R)-ethyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-(1H-indol-3-yl)propanamido)-3-((1-(3-(5-(dimethylamino)naphthalene-1-sulfonamido)propyl)-1H-1,2,3-triazol-4-yl)thio)propanoate

Synonyms:(R)-ethyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-(1H-indol-3-yl)propanamido)-3-((1-(3-(5-(dimethylamino)naphthalene-1-sulfonamido)propyl)-1H-1,2,3-triazol-4-yl)thio)propanoate

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Chemical Property of (R)-ethyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-(1H-indol-3-yl)propanamido)-3-((1-(3-(5-(dimethylamino)naphthalene-1-sulfonamido)propyl)-1H-1,2,3-triazol-4-yl)thio)propanoate

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Technology Process of (R)-ethyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-(1H-indol-3-yl)propanamido)-3-((1-(3-(5-(dimethylamino)naphthalene-1-sulfonamido)propyl)-1H-1,2,3-triazol-4-yl)thio)propanoate

There total 4 articles about (R)-ethyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-(1H-indol-3-yl)propanamido)-3-((1-(3-(5-(dimethylamino)naphthalene-1-sulfonamido)propyl)-1H-1,2,3-triazol-4-yl)thio)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1452252-77-5
C₂₆H₂₇N₃O₅S

: 610794-21-3
5-dimethylaminonaphthalene-1-sulfonic acid (3-azidopropyl)amide

: 1443746-73-3
(R)-ethyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-(1H-indol-3-yl)propanamido)-3-((1-(3-(5-(dimethylamino)naphthalene-1-sulfonamido)propyl)-1H-1,2,3-triazol-4-yl)thio)propanoate

Guidance literature:: With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In chloroform; water; at 20 ℃; for 24h;
DOI:10.1021/ja4044196

Reference yield:

: 7432-21-5
N-carbobenzyloxy-L-tryptophane

: 1443746-73-3
(R)-ethyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-(1H-indol-3-yl)propanamido)-3-((1-(3-(5-(dimethylamino)naphthalene-1-sulfonamido)propyl)-1H-1,2,3-triazol-4-yl)thio)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.17 h / 0 °C

1.2: 17 h / 20 °C

2.1: N,N,N',N'-tetramethylguanidine; L-lysine; L-histidine / tetrahydrofuran; water / 0.08 h / 20 °C

2.2: 0.01 h / 20 °C

3.1: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 10 h / 0 - 20 °C

4.1: sodium L-ascorbate; copper(ll) sulfate pentahydrate / water; chloroform / 24 h / 20 °C

With copper(ll) sulfate pentahydrate; L-lysine; tetrabutyl ammonium fluoride; benzotriazol-1-ol; acetic acid; sodium L-ascorbate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; L-histidine; N,N,N',N'-tetramethylguanidine; In tetrahydrofuran; dichloromethane; chloroform; water;
DOI:10.1021/ja4044196

Reference yield:

: 1443746-72-2
(R)-ethyl 2-((S)-2-((1H-indol-3-yl)methyl)-3-(((benzyloxy)carbonyl)amino)-3-oxopropanamido)-3-mercaptopropanoate

: 1443746-73-3
(R)-ethyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-(1H-indol-3-yl)propanamido)-3-((1-(3-(5-(dimethylamino)naphthalene-1-sulfonamido)propyl)-1H-1,2,3-triazol-4-yl)thio)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,N,N',N'-tetramethylguanidine; L-lysine; L-histidine / tetrahydrofuran; water / 0.08 h / 20 °C

1.2: 0.01 h / 20 °C

2.1: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 10 h / 0 - 20 °C

3.1: sodium L-ascorbate; copper(ll) sulfate pentahydrate / water; chloroform / 24 h / 20 °C

With copper(ll) sulfate pentahydrate; L-lysine; tetrabutyl ammonium fluoride; acetic acid; sodium L-ascorbate; L-histidine; N,N,N',N'-tetramethylguanidine; In tetrahydrofuran; chloroform; water;
DOI:10.1021/ja4044196