(R)-ethyl 2-((S)-2-((1H-indol-3-yl)methyl)-3-(((benzyloxy)carbonyl)amino)-3-oxopropanamido)-3-mercaptopropanoate

Base Information

Chemical Name:(R)-ethyl 2-((S)-2-((1H-indol-3-yl)methyl)-3-(((benzyloxy)carbonyl)amino)-3-oxopropanamido)-3-mercaptopropanoate
CAS No.:1443746-72-2
Molecular Formula:C₂₄H₂₇N₃O₅S
Molecular Weight:469.561
Hs Code.:

Synonyms:(R)-ethyl 2-((S)-2-((1H-indol-3-yl)methyl)-3-(((benzyloxy)carbonyl)amino)-3-oxopropanamido)-3-mercaptopropanoate

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Chemical Property of (R)-ethyl 2-((S)-2-((1H-indol-3-yl)methyl)-3-(((benzyloxy)carbonyl)amino)-3-oxopropanamido)-3-mercaptopropanoate

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Technology Process of (R)-ethyl 2-((S)-2-((1H-indol-3-yl)methyl)-3-(((benzyloxy)carbonyl)amino)-3-oxopropanamido)-3-mercaptopropanoate

There total 1 articles about (R)-ethyl 2-((S)-2-((1H-indol-3-yl)methyl)-3-(((benzyloxy)carbonyl)amino)-3-oxopropanamido)-3-mercaptopropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 868-59-7
L-cysteine ethyl ester hydrochloride

: 7432-21-5
N-carbobenzyloxy-L-tryptophane

: 1443746-72-2
(R)-ethyl 2-((S)-2-((1H-indol-3-yl)methyl)-3-(((benzyloxy)carbonyl)amino)-3-oxopropanamido)-3-mercaptopropanoate

Guidance literature:: L-cysteine ethyl ester hydrochloride; N-carbobenzyloxy-L-tryptophane; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 ℃; for 0.166667h;

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 17h;
DOI:10.1021/ja4044196

Reference yield: 97.0%

: 1443746-72-2
(R)-ethyl 2-((S)-2-((1H-indol-3-yl)methyl)-3-(((benzyloxy)carbonyl)amino)-3-oxopropanamido)-3-mercaptopropanoate

: 181934-30-5
1-[(triisopropylsilyl)ethynyl]-1,2-benziodoxol-3(1H)-one

: 1443746-68-6
(R)-ethyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-(1H-indol-3-yl)propanamido)-3-(((triisopropylsilyl)ethynyl)thio)propanoate

Guidance literature:: (R)-ethyl 2-((S)-2-((1H-indol-3-yl)methyl)-3-(((benzyloxy)carbonyl)amino)-3-oxopropanamido)-3-mercaptopropanoate; With L-lysine; L-histidine; N,N,N',N'-tetramethylguanidine; In tetrahydrofuran; water; at 20 ℃; for 0.0833333h;

1-[(triisopropylsilyl)ethynyl]-1,2-benziodoxol-3(1H)-one; In tetrahydrofuran; water; at 20 ℃; for 0.00833333h; chemoselective reaction;
DOI:10.1021/ja4044196

Reference yield: 83.0%

: 1443746-72-2
(R)-ethyl 2-((S)-2-((1H-indol-3-yl)methyl)-3-(((benzyloxy)carbonyl)amino)-3-oxopropanamido)-3-mercaptopropanoate

: 1-(hexadecynyl)-1,2-benziodoxol-3(1H)-one

: ethyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-(1H-indol-3-yl)propanamido)-3-(hexadec-1-yn-1-ylthio)propanoate

Guidance literature:: (R)-ethyl 2-((S)-2-((1H-indol-3-yl)methyl)-3-(((benzyloxy)carbonyl)amino)-3-oxopropanamido)-3-mercaptopropanoate; With N,N,N',N'-tetramethylguanidine; In tetrahydrofuran; at 24 ℃; for 0.0833333h;

1-(hexadecynyl)-1,2-benziodoxol-3(1H)-one; In tetrahydrofuran; at 23 ℃; for 0.0833333h;
DOI:10.1021/ja5083014