Ethyl-4-(benzyloxy)-3-carbamoyl-1,2-dihydro-5-methoxy-3H,6H-pyrrolo<3,2-e>indol-7-carboxylat

Base Information

• Chemical Name: Ethyl-4-(benzyloxy)-3-carbamoyl-1,2-dihydro-5-methoxy-3H,6H-pyrrolo<3,2-e>indol-7-carboxylat
• CAS No.: 127028-09-5
• Molecular Formula: C₂₂H₂₃N₃O₅
• Molecular Weight: 409.442
• Mol file: 127028-09-5.mol

Synonyms:Ethyl-4-(benzyloxy)-3-carbamoyl-1,2-dihydro-5-methoxy-3H,6H-pyrrolo<3,2-e>indol-7-carboxylat

Chemical Property of Ethyl-4-(benzyloxy)-3-carbamoyl-1,2-dihydro-5-methoxy-3H,6H-pyrrolo<3,2-e>indol-7-carboxylat

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Ethyl-4-(benzyloxy)-3-carbamoyl-1,2-dihydro-5-methoxy-3H,6H-pyrrolo<3,2-e>indol-7-carboxylat

There total 5 articles about Ethyl-4-(benzyloxy)-3-carbamoyl-1,2-dihydro-5-methoxy-3H,6H-pyrrolo<3,2-e>indol-7-carboxylat which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

sodium isocyanate (917-61-3) + Ethyl-4-(benzyloxy)-1,2-dihydro-5-methoxy-3H,6H-pyrrolo<3,2-e>indol-7-carboxylat → Ethyl-4-(benzyloxy)-3-carbamoyl-1,2-dihydro-5-methoxy-3H,6H-pyrrolo<3,2-e>indol-7-carboxylat (127028-09-5)

Guidance literature:

With acetic acid; at 50 ℃; for 0.25h;

DOI:10.1002/hlca.19890720717

Reference yield:

7-benzyloxy-6-methoxy-1H-indole-4-carbaldehyde (102357-91-5) → Ethyl-4-(benzyloxy)-3-carbamoyl-1,2-dihydro-5-methoxy-3H,6H-pyrrolo<3,2-e>indol-7-carboxylat (127028-09-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 72 percent / Na / ethanol; tetrahydrofuran / 6 h / -65 °C

2: 92 percent / xylene / 0.17 h / Heating

3: 48 percent / NaBH₃CN, AcOH / 2.5 h / 15 °C

4: 90 percent / AcOH / 0.25 h / 50 °C

With sodium; sodium cyanoborohydride; acetic acid; In tetrahydrofuran; ethanol; xylene;

DOI:10.1002/hlca.19890720717

Reference yield:

1-Acetyl-7-(benzyloxy)-6-methoxyindol-4-carbaldehyd (127028-02-8) → Ethyl-4-(benzyloxy)-3-carbamoyl-1,2-dihydro-5-methoxy-3H,6H-pyrrolo<3,2-e>indol-7-carboxylat (127028-09-5)

Guidance literature:

Multi-step reaction with 5 steps

1: 91 percent / NaOH / methanol / 1 h / Ambient temperature

2: 72 percent / Na / ethanol; tetrahydrofuran / 6 h / -65 °C

3: 92 percent / xylene / 0.17 h / Heating

4: 48 percent / NaBH₃CN, AcOH / 2.5 h / 15 °C

5: 90 percent / AcOH / 0.25 h / 50 °C

With sodium hydroxide; sodium; sodium cyanoborohydride; acetic acid; In tetrahydrofuran; methanol; ethanol; xylene;

DOI:10.1002/hlca.19890720717

upstream raw materials:

sodium isocyanate

7-benzyloxy-6-methoxy-1H-indole-4-carbaldehyde

1-Acetyl-7-(benzyloxy)-6-methoxyindol-4-carbaldehyd

Refernces