102357-91-5Relevant academic research and scientific papers
Novel syntheses of optically active CC-1065, U-73,975(adozelesin), U-80,244(carzelesin), U-77,779(bizelesin), KW-2189, and DU-86
Fukuda, Yasumichi,Furuta, Hirosuke,Shiga, Futoshi,Asahina, Yoshikazu,Terashima, Shiro
, p. 2303 - 2308 (2007/10/03)
The title syntheses were achieved by the method featuring oxidative cyclization of the enamino esters [(S)-13 and (S)-24] derived from the 5-aminoindoline [(5)-12], acylation with various structural types of indole-2-carboxylic acids, and formation of cyclopropapyrroloindole moieties.
A Novel Entry to 4,7-Indoloquinones via the Fremy's Salt Oxidative Degradation of 4-Formyl-7-hydroxyindoles
Saa, Jose M.,Marti, Catalina,Garcia-Raso, Angel
, p. 589 - 594 (2007/10/02)
A novel synthetic approach toward 4-formyl-7-hydroxyindoles and 4,7-indoloquinones is described.Basically, two major operations need to be carried out, namely: (1) ozonization of the appropriately protected 4-amino-5-hydroxyindenes leading eventually to 4-formyl-7-hydroxyindoles and (2) Fremy's salt promoted oxidative degradation of the later compounds to the desired 4,7-indoloquinones.A formal synthesis of PDE I and PDE II has been achieved.
Vinyl Azides in Heterocyclic Synthesis. Part 8. Synthesis of the Naturally Occuring Phosphodiesterase Inhibitors PDE-I and PDE-II
Bolton, Richard E.,Moody, Christopher, J.,Rees, Charles W.,Tojo, Gabriel
, p. 931 - 936 (2007/10/02)
The synthesis of the naturally occuring pyrroloindole phosphodiesterase inhibitors PDE-I (1) and PDE-II (2) from isovanillin is described.The route involves the construction of both pyrrole rings by vinylnitrene cyclisations, the key cyclisation substrates being the azidoacrylates (5) and (11), prepared from the aldehydes (4) and (10) respectively.The tricyclic intermediate (12) is converted into both PDE-I and PDE-II by selective reduction, followed by carbamoylation or acetylation respectively, and deprotection.
Synthesis of the Phosphodiesterase Inhibitors PDE-I and PDE-II
Bolton, Richard E.,Moody, Christopher J.,Rees, Charles W.,Tojo, Gabriel
, p. 1775 - 1776 (2007/10/02)
The pyrroloindole phosphodiesterase inhibitors PDE-I (1) and PDE-II (2) have been synthesised from isovanilin by a route which involves construction of both pyrrole rings by thermolysis of azidoacrylates readily derived from benzaldehydes.
