(R)-(+)-3-<(2,2-dimethyl-1,3-dioxolanyl)methyl>-2,2-diphenylpropionic acid

Base Information

Chemical Name:(R)-(+)-3-<(2,2-dimethyl-1,3-dioxolanyl)methyl>-2,2-diphenylpropionic acid
CAS No.:144042-74-0
Molecular Formula:C₂₀H₂₂O₄
Molecular Weight:326.392
Hs Code.:

Synonyms:(R)-(+)-3-<(2,2-dimethyl-1,3-dioxolanyl)methyl>-2,2-diphenylpropionic acid

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Chemical Property of (R)-(+)-3-<(2,2-dimethyl-1,3-dioxolanyl)methyl>-2,2-diphenylpropionic acid

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Technology Process of (R)-(+)-3-<(2,2-dimethyl-1,3-dioxolanyl)methyl>-2,2-diphenylpropionic acid

There total 2 articles about (R)-(+)-3-<(2,2-dimethyl-1,3-dioxolanyl)methyl>-2,2-diphenylpropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 14347-78-5,36543-79-0
1,2-O-isopropylidene-D-glycerol

: 144042-74-0
(R)-(+)-3-<(2,2-dimethyl-1,3-dioxolanyl)methyl>-2,2-diphenylpropionic acid

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / CH₂Cl₂

2: NaI / dimethylformamide

3: 1.) lithium diisopropylamide / 1.) THF, a) 25 deg C, 30 min, b) 70 deg C, 1 h, 2.) THF, a) 0 deg C, 30 min, b) RT, 20 h

With triethylamine; sodium iodide; lithium diisopropyl amide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00101a019

Reference yield:

: 23735-43-5,7305-59-1
(S)-1-O-tosyl-2,3-O-isopropylideneglycerol

: 144042-74-0
(R)-(+)-3-<(2,2-dimethyl-1,3-dioxolanyl)methyl>-2,2-diphenylpropionic acid

Guidance literature:: Multi-step reaction with 2 steps

1: NaI / dimethylformamide

2: 1.) lithium diisopropylamide / 1.) THF, a) 25 deg C, 30 min, b) 70 deg C, 1 h, 2.) THF, a) 0 deg C, 30 min, b) RT, 20 h

With sodium iodide; lithium diisopropyl amide; In N,N-dimethyl-formamide;
DOI:10.1021/jm00101a019