3-(1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-(3-hydroxy-naphthalen-2-yl)-1-methyl-pyrrole-2,5-dione

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Chemical Name:3-(1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-(3-hydroxy-naphthalen-2-yl)-1-methyl-pyrrole-2,5-dione
CAS No.:1027500-17-9
Molecular Formula:C₂₈H₁₉N₃O₅S
Molecular Weight:509.542
Hs Code.:

Synonyms:3-(1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-(3-hydroxy-naphthalen-2-yl)-1-methyl-pyrrole-2,5-dione

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Chemical Property of 3-(1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-(3-hydroxy-naphthalen-2-yl)-1-methyl-pyrrole-2,5-dione

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Technology Process of 3-(1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-(3-hydroxy-naphthalen-2-yl)-1-methyl-pyrrole-2,5-dione

There total 4 articles about 3-(1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-(3-hydroxy-naphthalen-2-yl)-1-methyl-pyrrole-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 447408-25-5
3-(1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-bromo-1-methylpyrrole-2,5-dione

: 849404-37-1
(3-hydroxynaphthalen-2-yl) boronic acid

: 1027500-17-9
3-(1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-(3-hydroxy-naphthalen-2-yl)-1-methyl-pyrrole-2,5-dione

Guidance literature:: With palladium diacetate; potassium carbonate; In 1,4-dioxane; at 100 ℃; for 2h;
DOI:10.1021/jm049213f

Reference yield:

: 93-04-9
2-Methoxynaphthalene

: 1027500-17-9
3-(1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-(3-hydroxy-naphthalen-2-yl)-1-methyl-pyrrole-2,5-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 2 h / -10 - 0 °C

1.2: hexane; tetrahydrofuran / 1 h / 20 °C

2.1: 1.99 g / aq. HCl / hexane; tetrahydrofuran

3.1: 85 percent / BBr₃ / CH₂Cl₂ / 2 h / 20 °C

4.1: 81 percent / Pd(OAc)2; aq. K₂CO₃ / dioxane / 2 h / 100 °C

With hydrogenchloride; palladium diacetate; n-butyllithium; boron tribromide; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; 4.1: Suzuki coupling reaction;
DOI:10.1021/jm049213f

Reference yield:

: 104115-76-6
3-methoxynaphthalen-2-ylboronic acid

: 1027500-17-9
3-(1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-(3-hydroxy-naphthalen-2-yl)-1-methyl-pyrrole-2,5-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / BBr₃ / CH₂Cl₂ / 2 h / 20 °C

2: 81 percent / Pd(OAc)2; aq. K₂CO₃ / dioxane / 2 h / 100 °C

With palladium diacetate; boron tribromide; potassium carbonate; In 1,4-dioxane; dichloromethane; 2: Suzuki coupling reaction;
DOI:10.1021/jm049213f