AC-DL-PRA-OET

Base Information

• Chemical Name: AC-DL-PRA-OET
• CAS No.: 23235-05-4
• Molecular Formula: C9H13 N O3
• Molecular Weight: 183.207
• Hs Code.: 2924199090
• Mol file: 23235-05-4.mol

Synonyms:4-Pentynoicacid, 2-(acetylamino)-, ethyl ester, (?à)-; 4-Pentynoic acid, 2-acetamido-, ethyl ester, DL-(8CI); 2-(Acetylamino)-4-pentynoic acid ethyl ester

Chemical Property of AC-DL-PRA-OET

Chemical Property:

• PSA: 58.89000
• LogP: 0.91780
• Storage Temp.: -15°C

Purity/Quality:

98%Min ^*data from raw suppliers

Acetyl-DL-propargylglycine ethyl ester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Precursor of tritiated norleucine.

Technology Process of AC-DL-PRA-OET

There total 5 articles about AC-DL-PRA-OET which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

ethyl 2-aminopent-4-ynoate (100860-41-1) + acetic anhydride (108-24-7) → L,D-acetylpropargylglycine ethyl ester (23235-05-4)

Guidance literature:

With dmap; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1016/S0040-4020(02)01178-X

Reference yield:

diethyl α-acetamido-α-propargylmalonate (61172-60-9) → L,D-acetylpropargylglycine ethyl ester (23235-05-4)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaOH

2: HCl

With hydrogenchloride; sodium hydroxide;

Reference yield:

ethyl 2-[(diphenylmethylidene)amino]pent-4-ynoate (171922-16-0) → L,D-acetylpropargylglycine ethyl ester (23235-05-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 68 percent / 1N HCl / diethyl ether / 12 h / 20 °C

2: 74 percent / DMAP / CH₂Cl₂ / 24 h / 20 °C

With hydrogenchloride; dmap; In diethyl ether; dichloromethane;

DOI:10.1016/S0040-4020(02)01178-X

upstream raw materials:

ethanol

N-Acetyl-α-propargylglycine

ethyl 2-aminopent-4-ynoate

acetic anhydride

Downstream raw materials:

2-Acetylamino-pent-4-ynoic acid 4-nitro-benzyl ester

Ac-β-(1-(3,5-dimethoxybenzyl)-1,2,3-triazol-5-yl)-Ala-OEt

Ac-β-((1-benzyl)-1,2,3-triazol-5-yl)-Ala-OEt

2-(acetamido)-3-(4,7-dimethyl-2-tosylisoindolin-5-yl)propanoic acid ethyl ester