(11α,13E,15S)-11,15-dihydroxy-9-oxoprost-13-en-1-oic acid 4-(3H-1,2-dithiole-3-thione-5-yl)-phenyl ester

Base Information

Chemical Name:(11α,13E,15S)-11,15-dihydroxy-9-oxoprost-13-en-1-oic acid 4-(3H-1,2-dithiole-3-thione-5-yl)-phenyl ester
CAS No.:1088434-84-7
Molecular Formula:C₂₉H₃₈O₅S₃
Molecular Weight:562.816
Hs Code.:

Synonyms:(11α,13E,15S)-11,15-dihydroxy-9-oxoprost-13-en-1-oic acid 4-(3H-1,2-dithiole-3-thione-5-yl)-phenyl ester

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Chemical Property of (11α,13E,15S)-11,15-dihydroxy-9-oxoprost-13-en-1-oic acid 4-(3H-1,2-dithiole-3-thione-5-yl)-phenyl ester

Chemical Property:

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Technology Process of (11α,13E,15S)-11,15-dihydroxy-9-oxoprost-13-en-1-oic acid 4-(3H-1,2-dithiole-3-thione-5-yl)-phenyl ester

There total 3 articles about (11α,13E,15S)-11,15-dihydroxy-9-oxoprost-13-en-1-oic acid 4-(3H-1,2-dithiole-3-thione-5-yl)-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 18274-81-2
desmethyl anethole trithione

: 745-65-3
ALPROSTADIL

: 1088434-84-7
(11α,13E,15S)-11,15-dihydroxy-9-oxoprost-13-en-1-oic acid 4-(3H-1,2-dithiole-3-thione-5-yl)-phenyl ester

Guidance literature:: desmethyl anethole trithione; ALPROSTADIL; dmap; In tetrahydrofuran; at 0 ℃; Inert atmosphere;

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; at 20 ℃; for 15h; Inert atmosphere;

Reference yield:

: 532-11-6
anethole trithione

: 1088434-84-7
(11α,13E,15S)-11,15-dihydroxy-9-oxoprost-13-en-1-oic acid 4-(3H-1,2-dithiole-3-thione-5-yl)-phenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine hydrochloride / 0.42 h / 215 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dmap / tetrahydrofuran / 15 h / 0 - 20 °C

With pyridine hydrochloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; In tetrahydrofuran;

Reference yield:

: 4180-23-8,25086-72-0,63589-56-0
E-1-(4'-methoxyphenyl)prop-1-ene

: 1088434-84-7
(11α,13E,15S)-11,15-dihydroxy-9-oxoprost-13-en-1-oic acid 4-(3H-1,2-dithiole-3-thione-5-yl)-phenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: sulfur / ISOPROPYLAMIDE / 6 h / 145 °C

2: pyridine hydrochloride / 0.42 h / 215 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dmap / tetrahydrofuran / 15 h / 0 - 20 °C

With pyridine hydrochloride; sulfur; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; In tetrahydrofuran; ISOPROPYLAMIDE;