(2R,6S,7R/S)-1-tert-butyldiphenylsilyloxy-2,6-dimethyl-7-tetrahydropyranyloxyoctane

Base Information

Chemical Name:(2R,6S,7R/S)-1-tert-butyldiphenylsilyloxy-2,6-dimethyl-7-tetrahydropyranyloxyoctane
CAS No.:270073-65-9
Molecular Formula:C₃₁H₄₈O₃Si
Molecular Weight:496.806
Hs Code.:

Synonyms:(2R,6S,7R/S)-1-tert-butyldiphenylsilyloxy-2,6-dimethyl-7-tetrahydropyranyloxyoctane

Suppliers and Price of (2R,6S,7R/S)-1-tert-butyldiphenylsilyloxy-2,6-dimethyl-7-tetrahydropyranyloxyoctane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,6S,7R/S)-1-tert-butyldiphenylsilyloxy-2,6-dimethyl-7-tetrahydropyranyloxyoctane

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Technology Process of (2R,6S,7R/S)-1-tert-butyldiphenylsilyloxy-2,6-dimethyl-7-tetrahydropyranyloxyoctane

There total 6 articles about (2R,6S,7R/S)-1-tert-butyldiphenylsilyloxy-2,6-dimethyl-7-tetrahydropyranyloxyoctane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 110-87-2
3,4-dihydro-2H-pyran

: 250229-64-2
(2S/R,3S,7R)-8-tert-butyldiphenylsilyloxy-3,7-dimethyl-2-octanol

: 270073-65-9
(2R,6S,7R/S)-1-tert-butyldiphenylsilyloxy-2,6-dimethyl-7-tetrahydropyranyloxyoctane

Guidance literature:: With toluene-4-sulfonic acid; In diethyl ether; at 20 ℃; for 4h;
DOI:10.1002/1099-0690(200004)2000:7<1307::AID-EJOC1307>3.0.CO;2-X

Reference yield:

: 101382-88-1
(2S,6R)-7-tert-butyldiphenylsilyloxy-2,6-dimethyl-1-heptanol

: 270073-65-9
(2R,6S,7R/S)-1-tert-butyldiphenylsilyloxy-2,6-dimethyl-7-tetrahydropyranyloxyoctane

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / Dess-Martin periodinane / pyridine; CH₂Cl₂

2: 88 percent / tetrahydrofuran / 1 h / -78 °C

3: 98 percent / p-toluenesulfonic acid monohydrate / diethyl ether / 4 h / 20 °C

With Dess-Martin periodane; toluene-4-sulfonic acid; In tetrahydrofuran; pyridine; diethyl ether; dichloromethane; 1: Oxidation / 2: Grignard reaction / 3: Etherification;
DOI:10.1002/1099-0690(200004)2000:7<1307::AID-EJOC1307>3.0.CO;2-X

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 270073-65-9
(2R,6S,7R/S)-1-tert-butyldiphenylsilyloxy-2,6-dimethyl-7-tetrahydropyranyloxyoctane

Guidance literature:: Multi-step reaction with 5 steps

1: 96 percent / imidazole / dimethylformamide

2: 99 percent / K₂CO₃ / methanol

3: 95 percent / Dess-Martin periodinane / pyridine; CH₂Cl₂

4: 88 percent / tetrahydrofuran / 1 h / -78 °C

5: 98 percent / p-toluenesulfonic acid monohydrate / diethyl ether / 4 h / 20 °C

With 1H-imidazole; potassium carbonate; Dess-Martin periodane; toluene-4-sulfonic acid; In tetrahydrofuran; pyridine; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; 1: Substitution / 2: Hydrolysis / 3: Oxidation / 4: Grignard reaction / 5: Etherification;
DOI:10.1002/1099-0690(200004)2000:7<1307::AID-EJOC1307>3.0.CO;2-X