7-(2-bromo-phenyl)-3,7,8,8a-tetrahydro-5H-pyrido[4,3-c]pyridazine-1,2,6-tricarboxylic acid 1,2-di-tert-butyl ester 6-methyl ester

Base Information

Chemical Name:7-(2-bromo-phenyl)-3,7,8,8a-tetrahydro-5H-pyrido[4,3-c]pyridazine-1,2,6-tricarboxylic acid 1,2-di-tert-butyl ester 6-methyl ester
CAS No.:1296216-98-2
Molecular Formula:C₂₅H₃₄BrN₃O₆
Molecular Weight:552.465
Hs Code.:

Synonyms:7-(2-bromo-phenyl)-3,7,8,8a-tetrahydro-5H-pyrido[4,3-c]pyridazine-1,2,6-tricarboxylic acid 1,2-di-tert-butyl ester 6-methyl ester

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Chemical Property of 7-(2-bromo-phenyl)-3,7,8,8a-tetrahydro-5H-pyrido[4,3-c]pyridazine-1,2,6-tricarboxylic acid 1,2-di-tert-butyl ester 6-methyl ester

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Technology Process of 7-(2-bromo-phenyl)-3,7,8,8a-tetrahydro-5H-pyrido[4,3-c]pyridazine-1,2,6-tricarboxylic acid 1,2-di-tert-butyl ester 6-methyl ester

There total 2 articles about 7-(2-bromo-phenyl)-3,7,8,8a-tetrahydro-5H-pyrido[4,3-c]pyridazine-1,2,6-tricarboxylic acid 1,2-di-tert-butyl ester 6-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 870-50-8
di-tert-butyl-diazodicarboxylate

: 1296216-96-0
2-(2-bromo-phenyl)-5-vinyl-3,6-dihydro-2H-pyridine-1-carboxylic acid methyl ester

: 1296216-98-2
7-(2-bromo-phenyl)-3,7,8,8a-tetrahydro-5H-pyrido[4,3-c]pyridazine-1,2,6-tricarboxylic acid 1,2-di-tert-butyl ester 6-methyl ester

Guidance literature:: at 90 ℃; for 12.5h; Inert atmosphere;
DOI:10.1021/ol200709h

Reference yield:

: 1296216-93-7
[1-(2-bromo-phenyl)-but-3-enyl]-prop-2-ynyl-carbamic acid methyl ester

: 1296216-98-2
7-(2-bromo-phenyl)-3,7,8,8a-tetrahydro-5H-pyrido[4,3-c]pyridazine-1,2,6-tricarboxylic acid 1,2-di-tert-butyl ester 6-methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: Grubbs catalyst first generation; ethene / dichloromethane / 11 h / 20 °C

2: 12.5 h / 90 °C / Inert atmosphere

With Grubbs catalyst first generation; ethene; In dichloromethane;
DOI:10.1021/ol200709h

Reference yield: 56.0%

: 1296216-98-2
7-(2-bromo-phenyl)-3,7,8,8a-tetrahydro-5H-pyrido[4,3-c]pyridazine-1,2,6-tricarboxylic acid 1,2-di-tert-butyl ester 6-methyl ester

: 1296216-99-3
7-(2-bromo-phenyl)-7,8-dihydro-5H-pyrido[4,3-c]pyridazine-6-carboxylic acidmethyl ester

Guidance literature:: 7-(2-bromo-phenyl)-3,7,8,8a-tetrahydro-5H-pyrido[4,3-c]pyridazine-1,2,6-tricarboxylic acid 1,2-di-tert-butyl ester 6-methyl ester; With bromine; In chloroform; at 0 - 20 ℃; for 1h; Inert atmosphere;

With water; sodium hydrogencarbonate; In chloroform;
DOI:10.1021/ol200709h