7-(2-bromo-phenyl)-7,8-dihydro-5H-pyrido[4,3-c]pyridazine-6-carboxylic acidmethyl ester

Base Information

Chemical Name:7-(2-bromo-phenyl)-7,8-dihydro-5H-pyrido[4,3-c]pyridazine-6-carboxylic acidmethyl ester
CAS No.:1296216-99-3
Molecular Formula:C₁₅H₁₄BrN₃O₂
Molecular Weight:348.199
Hs Code.:

Synonyms:7-(2-bromo-phenyl)-7,8-dihydro-5H-pyrido[4,3-c]pyridazine-6-carboxylic acidmethyl ester

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Chemical Property of 7-(2-bromo-phenyl)-7,8-dihydro-5H-pyrido[4,3-c]pyridazine-6-carboxylic acidmethyl ester

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Technology Process of 7-(2-bromo-phenyl)-7,8-dihydro-5H-pyrido[4,3-c]pyridazine-6-carboxylic acidmethyl ester

There total 3 articles about 7-(2-bromo-phenyl)-7,8-dihydro-5H-pyrido[4,3-c]pyridazine-6-carboxylic acidmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1296216-98-2
7-(2-bromo-phenyl)-3,7,8,8a-tetrahydro-5H-pyrido[4,3-c]pyridazine-1,2,6-tricarboxylic acid 1,2-di-tert-butyl ester 6-methyl ester

: 1296216-99-3
7-(2-bromo-phenyl)-7,8-dihydro-5H-pyrido[4,3-c]pyridazine-6-carboxylic acidmethyl ester

Guidance literature:: 7-(2-bromo-phenyl)-3,7,8,8a-tetrahydro-5H-pyrido[4,3-c]pyridazine-1,2,6-tricarboxylic acid 1,2-di-tert-butyl ester 6-methyl ester; With bromine; In chloroform; at 0 - 20 ℃; for 1h; Inert atmosphere;

With water; sodium hydrogencarbonate; In chloroform;
DOI:10.1021/ol200709h

Reference yield:

: 1296216-93-7
[1-(2-bromo-phenyl)-but-3-enyl]-prop-2-ynyl-carbamic acid methyl ester

: 1296216-99-3
7-(2-bromo-phenyl)-7,8-dihydro-5H-pyrido[4,3-c]pyridazine-6-carboxylic acidmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: Grubbs catalyst first generation; ethene / dichloromethane / 11 h / 20 °C

2: 12.5 h / 90 °C / Inert atmosphere

3: bromine / chloroform / 1 h / 0 - 20 °C / Inert atmosphere

With Grubbs catalyst first generation; ethene; bromine; In dichloromethane; chloroform;
DOI:10.1021/ol200709h

Reference yield:

: 1296216-96-0
2-(2-bromo-phenyl)-5-vinyl-3,6-dihydro-2H-pyridine-1-carboxylic acid methyl ester

: 1296216-99-3
7-(2-bromo-phenyl)-7,8-dihydro-5H-pyrido[4,3-c]pyridazine-6-carboxylic acidmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 12.5 h / 90 °C / Inert atmosphere

2: bromine / chloroform / 1 h / 0 - 20 °C / Inert atmosphere

With bromine; In chloroform;
DOI:10.1021/ol200709h