diphenylmethyl 7β-[(Z)-2-(thiazol-4-yl)-2-(trityloxyimino)acetamido]-3-[(1-tritylpyrazol-4-yl)methylthio]-3-cephem-4-carboxylate

Base Information

Chemical Name:diphenylmethyl 7β-[(Z)-2-(thiazol-4-yl)-2-(trityloxyimino)acetamido]-3-[(1-tritylpyrazol-4-yl)methylthio]-3-cephem-4-carboxylate
CAS No.:454472-41-4
Molecular Formula:C₆₇H₅₂N₆O₅S₃
Molecular Weight:1117.39
Hs Code.:

Synonyms:diphenylmethyl 7β-[(Z)-2-(thiazol-4-yl)-2-(trityloxyimino)acetamido]-3-[(1-tritylpyrazol-4-yl)methylthio]-3-cephem-4-carboxylate

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Chemical Property of diphenylmethyl 7β-[(Z)-2-(thiazol-4-yl)-2-(trityloxyimino)acetamido]-3-[(1-tritylpyrazol-4-yl)methylthio]-3-cephem-4-carboxylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of diphenylmethyl 7β-[(Z)-2-(thiazol-4-yl)-2-(trityloxyimino)acetamido]-3-[(1-tritylpyrazol-4-yl)methylthio]-3-cephem-4-carboxylate

There total 5 articles about diphenylmethyl 7β-[(Z)-2-(thiazol-4-yl)-2-(trityloxyimino)acetamido]-3-[(1-tritylpyrazol-4-yl)methylthio]-3-cephem-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 73151-05-0
(Z)-2-(4-thiazolyl)-2-(trityloxyimino)acetic acid

: 189099-17-0
diphenylmethyl 7β-amino-3-[(1-tritylpyrazol-4-yl)methylthio]-3-cephem-4-carboxylate

: 454472-41-4
diphenylmethyl 7β-[(Z)-2-(thiazol-4-yl)-2-(trityloxyimino)acetamido]-3-[(1-tritylpyrazol-4-yl)methylthio]-3-cephem-4-carboxylate

Guidance literature:: (Z)-2-(4-thiazolyl)-2-(trityloxyimino)acetic acid; With potassium carbonate; methanesulfonyl chloride; In N,N-dimethyl acetamide; at 5 ℃;

diphenylmethyl 7β-amino-3-[(1-tritylpyrazol-4-yl)methylthio]-3-cephem-4-carboxylate; With benzenesulfonamide; In N,N-dimethyl acetamide; at 5 ℃;
DOI:10.1016/S0968-0896(01)00416-3

Reference yield:

: 128438-00-6
ethyl (2-aminothiazol-4-yl)-2-(Z)-(trityloxyimino)acetate

: 454472-41-4
diphenylmethyl 7β-[(Z)-2-(thiazol-4-yl)-2-(trityloxyimino)acetamido]-3-[(1-tritylpyrazol-4-yl)methylthio]-3-cephem-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 62 percent / t-butylnitrate / tetrahydrofuran / 1 h / 50 °C

2.1: 84 percent / NaOH / dioxane; H₂O / 100 °C

3.1: K₂CO₃; MeSO₂Cl / N,N-dimethyl-acetamide / 5 °C

3.2: 100 percent / BSA / N,N-dimethyl-acetamide / 5 °C

With sodium hydroxide; tert-butyl nitrate; potassium carbonate; methanesulfonyl chloride; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl acetamide; water;
DOI:10.1016/S0968-0896(01)00416-3

Reference yield:

: 74704-03-3
diphenylmethyl 7β-amino-3-methanesulfonyloxy-3-cephem-4-carboxylate

: 454472-41-4
diphenylmethyl 7β-[(Z)-2-(thiazol-4-yl)-2-(trityloxyimino)acetamido]-3-[(1-tritylpyrazol-4-yl)methylthio]-3-cephem-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaSH; i-Pr₂NEt / dimethylformamide / 1 h / -20 °C

1.2: 56 percent / dimethylformamide / 1 h / -5 °C

2.1: K₂CO₃; MeSO₂Cl / N,N-dimethyl-acetamide / 5 °C

2.2: 100 percent / BSA / N,N-dimethyl-acetamide / 5 °C

With sodium hydrogensulfide; potassium carbonate; methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(01)00416-3