5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-amino-8-oxo-3-[[[1-(triphenylmethyl)-1H-pyrazol-4-yl]methyl]thio]-, diphenylmethyl ester, (6R,7R)-

Base Information

Chemical Name:5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-amino-8-oxo-3-[[[1-(triphenylmethyl)-1H-pyrazol-4-yl]methyl]thio]-, diphenylmethyl ester, (6R,7R)-
CAS No.:189099-17-0
Molecular Formula:C43H36N4O3S2
Molecular Weight:720.916
Hs Code.:

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,
7-amino-8-oxo-3-[[[1-(triphenylmethyl)-1H-pyrazol-4-yl]methyl]thio]-,
diphenylmethyl ester, (6R,7R)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-amino-8-oxo-3-[[[1-(triphenylmethyl)-1H-pyrazol-4-yl]methyl]thio]-, diphenylmethyl ester, (6R,7R)-

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Technology Process of 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-amino-8-oxo-3-[[[1-(triphenylmethyl)-1H-pyrazol-4-yl]methyl]thio]-, diphenylmethyl ester, (6R,7R)-

There total 1 articles about 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-amino-8-oxo-3-[[[1-(triphenylmethyl)-1H-pyrazol-4-yl]methyl]thio]-, diphenylmethyl ester, (6R,7R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 74704-03-3
diphenylmethyl 7β-amino-3-methanesulfonyloxy-3-cephem-4-carboxylate

: 4-chloromethyl-1-tritylpyrazole

: 189099-17-0
diphenylmethyl 7β-amino-3-[(1-tritylpyrazol-4-yl)methylthio]-3-cephem-4-carboxylate

Guidance literature:: diphenylmethyl 7β-amino-3-methanesulfonyloxy-3-cephem-4-carboxylate; With sodium hydrogensulfide; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at -20 ℃; for 1h;

4-chloromethyl-1-tritylpyrazole; In N,N-dimethyl-formamide; at -5 ℃; for 1h;
DOI:10.1016/S0968-0896(01)00416-3

Reference yield: 100.0%

: 73151-05-0
(Z)-2-(4-thiazolyl)-2-(trityloxyimino)acetic acid

: 189099-17-0
diphenylmethyl 7β-amino-3-[(1-tritylpyrazol-4-yl)methylthio]-3-cephem-4-carboxylate

: 454472-41-4
diphenylmethyl 7β-[(Z)-2-(thiazol-4-yl)-2-(trityloxyimino)acetamido]-3-[(1-tritylpyrazol-4-yl)methylthio]-3-cephem-4-carboxylate

Guidance literature:: (Z)-2-(4-thiazolyl)-2-(trityloxyimino)acetic acid; With potassium carbonate; methanesulfonyl chloride; In N,N-dimethyl acetamide; at 5 ℃;

diphenylmethyl 7β-amino-3-[(1-tritylpyrazol-4-yl)methylthio]-3-cephem-4-carboxylate; With benzenesulfonamide; In N,N-dimethyl acetamide; at 5 ℃;
DOI:10.1016/S0968-0896(01)00416-3

Reference yield: 90.0%

: 189099-04-5
(Z)-2-(acetoxyimino)-2-(2-amino-5-bromothiazol-4-yl)acetic acid

: 189099-17-0
diphenylmethyl 7β-amino-3-[(1-tritylpyrazol-4-yl)methylthio]-3-cephem-4-carboxylate

: 189099-22-7
diphenylmethyl 7β-[(Z)-2-(2-amino-5-bromothiazol-4-yl)-2-(acetoxyimino)acetamido]-3-[(1-tritylpyrazol-4-yl)methylthio]-3-cephem-4-carboxylate

Guidance literature:: (Z)-2-(acetoxyimino)-2-(2-amino-5-bromothiazol-4-yl)acetic acid; With potassium carbonate; methanesulfonyl chloride; In N,N-dimethyl acetamide; at 5 ℃;

diphenylmethyl 7β-amino-3-[(1-tritylpyrazol-4-yl)methylthio]-3-cephem-4-carboxylate; With benzenesulfonamide; In N,N-dimethyl acetamide; at 5 ℃;
DOI:10.1016/S0968-0896(01)00416-3