(S)-tert-butyl (3-(3,4-bis(benzyloxy)phenyl)-1-amino-1-oxopropan-2-yl)carbamate

Base Information

Chemical Name:(S)-tert-butyl (3-(3,4-bis(benzyloxy)phenyl)-1-amino-1-oxopropan-2-yl)carbamate
CAS No.:125228-00-4
Molecular Formula:C₂₈H₃₂N₂O₅
Molecular Weight:476.572
Hs Code.:

Synonyms:(S)-tert-butyl (3-(3,4-bis(benzyloxy)phenyl)-1-amino-1-oxopropan-2-yl)carbamate

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Chemical Property of (S)-tert-butyl (3-(3,4-bis(benzyloxy)phenyl)-1-amino-1-oxopropan-2-yl)carbamate

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Technology Process of (S)-tert-butyl (3-(3,4-bis(benzyloxy)phenyl)-1-amino-1-oxopropan-2-yl)carbamate

There total 6 articles about (S)-tert-butyl (3-(3,4-bis(benzyloxy)phenyl)-1-amino-1-oxopropan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 59727-98-9
3-[3,4-di(benzyloxy)phenyl]-2-{[(tert-butoxy)carbonyl]amino}propanoic acid

: 125228-00-4
(S)-tert-butyl (3-(3,4-bis(benzyloxy)phenyl)-1-amino-1-oxopropan-2-yl)carbamate

Guidance literature:: 3-[3,4-di(benzyloxy)phenyl]-2-{[(tert-butoxy)carbonyl]amino}propanoic acid; With 1-hydroxy-pyrrolidine-2,5-dione; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃;

With ammonia; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; for 4h;
DOI:10.1016/j.ejmech.2010.05.062

Reference yield:

: 37169-36-1
methyl (S)-2-(tert-butoxycarbonylamino)-3-(3,4-dihydroxyphenyl)propanoate

: 125228-00-4
(S)-tert-butyl (3-(3,4-bis(benzyloxy)phenyl)-1-amino-1-oxopropan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: K₂CO₃, NaI / ethanol / 3 h / Heating

2: 2N NaOH / methanol; H₂O / 1 h / Heating

3: triethylamine / CH₂Cl₂ / 1.5 h / 0 °C

4: NH₃ (gas) / CH₂Cl₂ / 1.) 0 deg C, 30 min, 2.) room temp., 30 min

With sodium hydroxide; ammonia; potassium carbonate; triethylamine; sodium iodide; In methanol; ethanol; dichloromethane; water;
DOI:10.1021/jm00166a009