N-BIOTINYL GLYCINE

Base Information

• Chemical Name: N-BIOTINYL GLYCINE
• CAS No.: 160390-90-9
• Molecular Formula: C₁₂H₁₉N₃O₄S
• Molecular Weight: 301.367
• Mol file: 160390-90-9.mol

Synonyms:[5-(2-oxohexahydrothieno[3,4-d]imidazol-6-yl)pentanoylamino]acetic acid

Chemical Property of N-BIOTINYL GLYCINE

Chemical Property:

• Vapor Pressure: 9.17E-23mmHg at 25°C
• Boiling Point: 721.3±55.0 °C(Predicted)
• PKA: 3.59±0.10(Predicted)
• Density: 1.300±0.06 g/cm3(Predicted)

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-Biotinyl glycine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-BIOTINYL GLYCINE

There total 5 articles about N-BIOTINYL GLYCINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

[5-((3aR,6S,6aS)-2-Oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoylamino]-acetic acid methyl ester → [5-(2-oxohexahydrothieno[3,4-d]imidazol-6-yl)pentanoylamino]acetic acid (160390-90-9)

Guidance literature:

With lithium hydroxide; In 1,4-dioxane;

DOI:10.1016/S0960-894X(02)00624-8

Reference yield: 81.0%

glycine (56-40-6,18875-39-3,25718-94-9) + biotin (58-85-5,22879-79-4) → [5-(2-oxohexahydrothieno[3,4-d]imidazol-6-yl)pentanoylamino]acetic acid (160390-90-9)

Guidance literature:

biotin; With tributyl-amine; isobutyl chloroformate; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

glycine; In N,N-dimethyl-formamide; at 5 ℃; for 2h;

DOI:10.1021/ja0476718

Reference yield:

biotin N-Hydroxysuccinimide ester (35013-72-0) + glycine (56-40-6,18875-39-3,25718-94-9) → [5-(2-oxohexahydrothieno[3,4-d]imidazol-6-yl)pentanoylamino]acetic acid (160390-90-9)

Guidance literature:

With sodium hydrogencarbonate; In water; acetone; at 20 ℃; for 12h;

DOI:10.1016/j.bmcl.2019.01.015

upstream raw materials:

biotin chloride

glycine

biotin

biotin N-Hydroxysuccinimide ester

Refernces

• 1、 Tian, Dan-mei,Qiao, Jia,Bao, Yu-zhou,Liu, Jie,Zhang, Xiao-kun,Sun, Xue-long,Zhang, You-wei,Yao, Xin-sheng,Tang, Jin-shan. "Design and synthesis of biotinylated cardiac glycosides for probing Nur77 protein inducting pathway". . p. 707 - 712. Retrieved 2019/01/22.