Technology Process of ((R)-2,2,4-Trimethyl-3-oxo-cyclohexyl)-thioacetic acid S-ethyl ester
There total 7 articles about ((R)-2,2,4-Trimethyl-3-oxo-cyclohexyl)-thioacetic acid S-ethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
pyridine; O-phenyl phosphorodichloridate;
In
dichloromethane;
at 20 ℃;
DOI:10.1039/c39900000997
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 80 percent / KOH / 400 °C
2: 98 percent / K2CO3 / acetone / 20 °C
3: 1a.) O3, 1b.) Ph3P, 2.) p-TsOH / 1a.) CH2Cl2, MeOH, -78 deg C, 2.) C6H6, reflux
4: 97 percent / H2 / 5percent Pd/C / ethyl acetate / 20 °C
5: 77 percent / potassium hexamethyldisilazide / 1,2-dimethoxy-ethane / -78 °C
6: 88 percent / LiI, pyridine / H2O / Heating
7: 99 percent / PhOPOCl2, pyridine / CH2Cl2 / 20 °C
With
pyridine; potassium hydroxide; hydrogen; potassium hexamethylsilazane; potassium carbonate; toluene-4-sulfonic acid; ozone; O-phenyl phosphorodichloridate; triphenylphosphine; lithium iodide;
palladium on activated charcoal;
In
1,2-dimethoxyethane; dichloromethane; water; ethyl acetate; acetone;
DOI:10.1039/c39900000997
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 98 percent / K2CO3 / acetone / 20 °C
2: 1a.) O3, 1b.) Ph3P, 2.) p-TsOH / 1a.) CH2Cl2, MeOH, -78 deg C, 2.) C6H6, reflux
3: 97 percent / H2 / 5percent Pd/C / ethyl acetate / 20 °C
4: 77 percent / potassium hexamethyldisilazide / 1,2-dimethoxy-ethane / -78 °C
5: 88 percent / LiI, pyridine / H2O / Heating
6: 99 percent / PhOPOCl2, pyridine / CH2Cl2 / 20 °C
With
pyridine; hydrogen; potassium hexamethylsilazane; potassium carbonate; toluene-4-sulfonic acid; ozone; O-phenyl phosphorodichloridate; triphenylphosphine; lithium iodide;
palladium on activated charcoal;
In
1,2-dimethoxyethane; dichloromethane; water; ethyl acetate; acetone;
DOI:10.1039/c39900000997
