tert-butyl ester of {2-[4-(2,3-difluorophenyl)piperazin-1-yl]-2-oxoethyl}carbamic acid

Base Information

Chemical Name:tert-butyl ester of {2-[4-(2,3-difluorophenyl)piperazin-1-yl]-2-oxoethyl}carbamic acid
CAS No.:946522-91-4
Molecular Formula:C₁₇H₂₃F₂N₃O₃
Molecular Weight:355.385
Hs Code.:

Synonyms:tert-butyl ester of {2-[4-(2,3-difluorophenyl)piperazin-1-yl]-2-oxoethyl}carbamic acid

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Chemical Property of tert-butyl ester of {2-[4-(2,3-difluorophenyl)piperazin-1-yl]-2-oxoethyl}carbamic acid

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Technology Process of tert-butyl ester of {2-[4-(2,3-difluorophenyl)piperazin-1-yl]-2-oxoethyl}carbamic acid

There total 1 articles about tert-butyl ester of {2-[4-(2,3-difluorophenyl)piperazin-1-yl]-2-oxoethyl}carbamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 876379-86-1
1-(2,3-difluorophenyl)piperazine

: 4530-20-5
BOC-glycine

: 946522-91-4
tert-butyl ester of {2-[4-(2,3-difluorophenyl)piperazin-1-yl]-2-oxoethyl}carbamic acid

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 17h;
DOI:10.1021/jm070443e

Reference yield:

: 946522-91-4
tert-butyl ester of {2-[4-(2,3-difluorophenyl)piperazin-1-yl]-2-oxoethyl}carbamic acid

: C₁₂H₁₅F₂N₃O

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1021/jm070443e

Reference yield:

: 946522-91-4
tert-butyl ester of {2-[4-(2,3-difluorophenyl)piperazin-1-yl]-2-oxoethyl}carbamic acid

: C₂₁H₂₀N₄O₃SF₂

Guidance literature:: Multi-step reaction with 2 steps

1: TFA / CH₂Cl₂ / 3 h / 20 °C

2: Et₃N / CH₂Cl₂ / 0 - 20 °C

With triethylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jm070443e