monoethyl suberate 4-bromoanilide

Base Information

• Chemical Name: monoethyl suberate 4-bromoanilide
• CAS No.: 265980-86-7
• Molecular Formula: C₁₆H₂₂BrNO₃
• Molecular Weight: 356.26
• Mol file: 265980-86-7.mol

Synonyms:monoethyl suberate 4-bromoanilide

Chemical Property of monoethyl suberate 4-bromoanilide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of monoethyl suberate 4-bromoanilide

There total 3 articles about monoethyl suberate 4-bromoanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

ethyl 8-chloro-8-oxooctanoate (14113-02-1) + 4-bromo-aniline (106-40-1) → monoethyl suberate 4-bromoanilide (265980-86-7)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 16h;

DOI:10.1002/(SICI)1099-1344(20000315)43:3<229::AID-JLCR307>3.0.CO;2-J

Reference yield: 81.0%

Ethyl hydrogen suberate (14113-01-0) + 4-bromo-aniline (106-40-1) → monoethyl suberate 4-bromoanilide (265980-86-7)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.bioorg.2019.103452

Reference yield:

Ethyl hydrogen suberate (14113-01-0) → monoethyl suberate 4-bromoanilide (265980-86-7)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl chloride / CH₂Cl₂

2: 92 percent / triethylamine / CH₂Cl₂ / 16 h / 20 °C

With oxalyl dichloride; triethylamine; In dichloromethane; 1: Chlorination / 2: Condensation;

DOI:10.1002/(SICI)1099-1344(20000315)43:3<229::AID-JLCR307>3.0.CO;2-J

upstream raw materials:

ethyl 8-chloro-8-oxooctanoate

4-bromo-aniline

Ethyl hydrogen suberate

Downstream raw materials:

monoethyl suberate [4-3H]anilide

N'-(4-bromophenyl)-N-hydroxyoctanediamide