dimethyl N-<4-<2-(2-pivaloylamino-4(3H)-oxo-7H-pyrrolo<2,3-d>pyrimidin-6-yl)ethyl>benzoyl>-L-glutamate

Base Information

Chemical Name:dimethyl N-<4-<2-(2-pivaloylamino-4(3H)-oxo-7H-pyrrolo<2,3-d>pyrimidin-6-yl)ethyl>benzoyl>-L-glutamate
CAS No.:151937-08-5
Molecular Formula:C₂₇H₃₃N₅O₇
Molecular Weight:539.588
Hs Code.:

Synonyms:dimethyl N-<4-<2-(2-pivaloylamino-4(3H)-oxo-7H-pyrrolo<2,3-d>pyrimidin-6-yl)ethyl>benzoyl>-L-glutamate

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Chemical Property of dimethyl N-<4-<2-(2-pivaloylamino-4(3H)-oxo-7H-pyrrolo<2,3-d>pyrimidin-6-yl)ethyl>benzoyl>-L-glutamate

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Technology Process of dimethyl N-<4-<2-(2-pivaloylamino-4(3H)-oxo-7H-pyrrolo<2,3-d>pyrimidin-6-yl)ethyl>benzoyl>-L-glutamate

There total 4 articles about dimethyl N-<4-<2-(2-pivaloylamino-4(3H)-oxo-7H-pyrrolo<2,3-d>pyrimidin-6-yl)ethyl>benzoyl>-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 151937-07-4
dimethyl N-<4-<2-(2-pivaloylamino-4(3H)-oxo-7H-pyrrolo<2,3-d>)pyrimidine-6-yl>ethynyl>-L-glutamate

: 151937-08-5
dimethyl N-<4-<2-(2-pivaloylamino-4(3H)-oxo-7H-pyrrolo<2,3-d>pyrimidin-6-yl)ethyl>benzoyl>-L-glutamate

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; dichloromethane; for 48h; under 2585.7 Torr; Ambient temperature;

Reference yield:

: 135352-72-6
Dimethyl N-(4-ethynylbenzoyl)-L-glutamate

: 151937-08-5
dimethyl N-<4-<2-(2-pivaloylamino-4(3H)-oxo-7H-pyrrolo<2,3-d>pyrimidin-6-yl)ethyl>benzoyl>-L-glutamate

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / Pd(PPh₃)4, CuI, Et₃N / dimethylformamide / 4 h / 60 °C

2: 72 percent / H₂ / 5percent Pd/C / CH₂Cl₂; methanol / 48 h / 2585.7 Torr / Ambient temperature

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 137281-08-4
N-(4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl)pivalamide

: 151937-08-5
dimethyl N-<4-<2-(2-pivaloylamino-4(3H)-oxo-7H-pyrrolo<2,3-d>pyrimidin-6-yl)ethyl>benzoyl>-L-glutamate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) Hg(OAc)2, glacial AcOH, 2.) I₂ / 1.) RT, 10 min, 2.) CH₂Cl₂, RT, overnight

2: 78 percent / Pd(PPh₃)4, CuI, Et₃N / dimethylformamide / 4 h / 60 °C

3: 72 percent / H₂ / 5percent Pd/C / CH₂Cl₂; methanol / 48 h / 2585.7 Torr / Ambient temperature

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; mercury(II) diacetate; hydrogen; iodine; acetic acid; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;