Propanamide, N-(4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethyl-

Base Information

• Chemical Name: Propanamide, N-(4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethyl-
• CAS No.: 137281-08-4
• Molecular Formula: C11H14 N4 O2
• Molecular Weight: 234.258
• Hs Code.: 2933990090
• Mol file: 137281-08-4.mol

Synonyms:Propanamide,N-(4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethyl- (9CI);1H-Pyrrolo[2,3-d]pyrimidine, propanamide deriv.;2,2-Dimethyl-N-(4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl)propionamide

Chemical Property of Propanamide, N-(4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethyl-

Chemical Property:

• PSA: 90.64000
• Density: 1.387g/cm³
• LogP: 1.30880
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

N-(4-Oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-2-yl)pivalamide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Propanamide, N-(4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethyl-

There total 7 articles about Propanamide, N-(4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2,2-dimethylpropanoic anhydride (1538-75-6) + 2-amino-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one (7355-55-7) → N-(4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl)pivalamide (137281-08-4)

Guidance literature:

at 120 ℃;

Reference yield: 93.0%

pivaloyl chloride (3282-30-2) + 2-amino-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one (7355-55-7) → N-(4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl)pivalamide (137281-08-4)

Guidance literature:

pivaloyl chloride; 2-amino-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one; With pyridine; at 90 ℃; for 2h;

With ammonium hydroxide; In methanol; at 20 ℃; for 0.5h;

DOI:10.1021/jm300810x

Reference yield: 47.0%

2-(pivaloylamino)-4(3H)-oxo-7-acetyl-7H-pyrrolo<2,3-d>pyrimidine (173850-03-8) → N-(4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl)pivalamide (137281-08-4) + 2-(pivaloylamino)-4(3H)-oxo-5,6-dihydro-7-acetyl-7H-pyrrolo<2,3-d>pyrimidine

Guidance literature:

With hydrogen; platinum(IV) oxide; In methanol; acetic acid; for 12h; under 2585.7 Torr;

DOI:10.1021/jo951471k

upstream raw materials:

pivaloyl chloride

2-amino-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one

2-(pivaloylamino)-4(3H)-oxo-7-acetyl-7H-pyrrolo<2,3-d>pyrimidine

2,6-diamino-5-(3,3-diethoxyethyl)pyrimidin-4(3H)-one

Downstream raw materials:

C₂₁H₂₀ClN₅O

C₁₈H₁₈ClIN₄O

dimethyl N-<4-<2-(2-pivaloylamino-4(3H)-oxo-7H-pyrrolo<2,3-d>pyrimidin-6-yl)ethyl>benzoyl>-L-glutamate

dimethyl N-<4-<2-(2-pivaloylamino-4(3H)-oxo-7H-pyrrolo<2,3-d>)pyrimidine-6-yl>ethynyl>-L-glutamate