(+/-)-9-Benzylamino-2-pyrimidin-4-yl-5,6,8,9-tetrahydro-7-oxa-1,4a-diaza-benzocyclohepten-4-one

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Chemical Name:(+/-)-9-Benzylamino-2-pyrimidin-4-yl-5,6,8,9-tetrahydro-7-oxa-1,4a-diaza-benzocyclohepten-4-one
CAS No.:1174896-29-7
Molecular Formula:C₁₉H₁₉N₅O₂
Molecular Weight:349.392
Hs Code.:

Synonyms:(+/-)-9-Benzylamino-2-pyrimidin-4-yl-5,6,8,9-tetrahydro-7-oxa-1,4a-diaza-benzocyclohepten-4-one

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Chemical Property of (+/-)-9-Benzylamino-2-pyrimidin-4-yl-5,6,8,9-tetrahydro-7-oxa-1,4a-diaza-benzocyclohepten-4-one

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Technology Process of (+/-)-9-Benzylamino-2-pyrimidin-4-yl-5,6,8,9-tetrahydro-7-oxa-1,4a-diaza-benzocyclohepten-4-one

There total 5 articles about (+/-)-9-Benzylamino-2-pyrimidin-4-yl-5,6,8,9-tetrahydro-7-oxa-1,4a-diaza-benzocyclohepten-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

: 1174896-52-6
(+/-)-9-amino-2-pyrimidin-4-yl-5,6,8,9-tetrahydro-7-oxa-1,4a-diaza-benzocyclohepten-4-one

: 100-52-7
benzaldehyde

: 1174896-29-7
(+/-)-9-Benzylamino-2-pyrimidin-4-yl-5,6,8,9-tetrahydro-7-oxa-1,4a-diaza-benzocyclohepten-4-one

Guidance literature:: (+/-)-9-amino-2-pyrimidin-4-yl-5,6,8,9-tetrahydro-7-oxa-1,4a-diaza-benzocyclohepten-4-one; benzaldehyde; With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; at 20 ℃; for 15h;

With sodium carbonate; In dichloromethane; water;

Reference yield:

: 64210-67-9
ethyl 3-oxo-3-(pyrimidin-4-yl)propanoate

: 1174896-29-7
(+/-)-9-Benzylamino-2-pyrimidin-4-yl-5,6,8,9-tetrahydro-7-oxa-1,4a-diaza-benzocyclohepten-4-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / ethanol / 0.17 h / 20 °C

1.2: 4 h / Heating / reflux

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.17 h / -40 °C

2.2: 0.33 h / -40 °C

3.1: ammonia / methanol / 4 h / 100 °C / Sealed tube

4.1: sodium tris(acetoxy)borohydride / acetic acid / dichloromethane / 15 h / 20 °C

With ammonia; sodium tris(acetoxy)borohydride; potassium carbonate; lithium hexamethyldisilazane; acetic acid; In tetrahydrofuran; methanol; ethanol; dichloromethane;

Reference yield:

: 1174896-50-4
2-pyrimidin-4-yl-5,6,8,9-tetrahydro-7-oxa-1,4a-diaza-benzocyclohepten-4-one

: 1174896-29-7
(+/-)-9-Benzylamino-2-pyrimidin-4-yl-5,6,8,9-tetrahydro-7-oxa-1,4a-diaza-benzocyclohepten-4-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.17 h / -40 °C

1.2: 0.33 h / -40 °C

2.1: ammonia / methanol / 4 h / 100 °C / Sealed tube

3.1: sodium tris(acetoxy)borohydride / acetic acid / dichloromethane / 15 h / 20 °C

With ammonia; sodium tris(acetoxy)borohydride; lithium hexamethyldisilazane; acetic acid; In tetrahydrofuran; methanol; dichloromethane;