2-<2-propyl-3-<3-<2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy>propoxy>thiophenoxy>benzoic acid methyl ester

Base Information

Chemical Name:2-<2-propyl-3-<3-<2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy>propoxy>thiophenoxy>benzoic acid methyl ester
CAS No.:152610-23-6
Molecular Formula:C₃₄H₃₅FO₅S
Molecular Weight:574.713
Hs Code.:

Synonyms:2-<2-propyl-3-<3-<2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy>propoxy>thiophenoxy>benzoic acid methyl ester

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Chemical Property of 2-<2-propyl-3-<3-<2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy>propoxy>thiophenoxy>benzoic acid methyl ester

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Technology Process of 2-<2-propyl-3-<3-<2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy>propoxy>thiophenoxy>benzoic acid methyl ester

There total 13 articles about 2-<2-propyl-3-<3-<2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy>propoxy>thiophenoxy>benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-{3-[3-(2-Benzyloxy-5-ethyl-4'-fluoro-biphenyl-4-yloxy)-propoxy]-2-propyl-phenylsulfanyl}-benzoic acid methyl ester

: 152610-23-6
2-<2-propyl-3-<3-<2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy>propoxy>thiophenoxy>benzoic acid methyl ester

Guidance literature:: With boron tribromide; In dichloromethane; at -78 ℃; for 1h; Yield given;
DOI:10.1021/jm00022a006

Reference yield:

: 29682-12-0
1-[4-(benzyloxy)-2-hydroxyphenyl]ethanone

: 152610-23-6
2-<2-propyl-3-<3-<2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy>propoxy>thiophenoxy>benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 82 percent / K₂CO₃ / dimethylsulfoxide; butan-2-one / 24 h / Heating

2: 69 percent / trifluoroacetic acid, triethylsilane / CCl₄ / 1.5 h / Ambient temperature

3: 73 percent / N-bromosuccinimide / CCl₄ / 6 h / Ambient temperature

4: 84 percent / Pd(PPh₃)4, aq. Na₂CO₃ / ethanol; benzene / 16 h / Heating

5: 66 percent / K₂CO₃, KI, DMSO / butan-2-one / 18 h / Heating

6: H₂ / 10percent Pd/C / ethyl acetate / 760 Torr / Ambient temperature

7: BBr₃ / CH₂Cl₂ / 1 h / -78 °C

With triethylsilane; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; boron tribromide; sodium carbonate; potassium carbonate; dimethyl sulfoxide; trifluoroacetic acid; potassium iodide; palladium on activated charcoal; In tetrachloromethane; ethanol; dichloromethane; dimethyl sulfoxide; ethyl acetate; butanone; benzene;
DOI:10.1021/jm00022a006

Reference yield:

: 71112-91-9
bis(2-bromophenyl) disulfide

: 152610-23-6
2-<2-propyl-3-<3-<2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy>propoxy>thiophenoxy>benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) n-BuLi / 1.) THF, -74 deg C, 30 min, 2.) THF, from -74 deg C to RT

2: 1.) n-BuLi / 1.) THF, -78 deg C, 15 min, 2.) THF, from -78 deg C to RT

3: HCl(g) / 18 h / Ambient temperature

4: 41 percent / 30 h / 175 °C

5: 66 percent / K₂CO₃, KI, DMSO / butan-2-one / 18 h / Heating

6: H₂ / 10percent Pd/C / ethyl acetate / 760 Torr / Ambient temperature

7: BBr₃ / CH₂Cl₂ / 1 h / -78 °C

With hydrogenchloride; n-butyllithium; hydrogen; boron tribromide; potassium carbonate; dimethyl sulfoxide; potassium iodide; palladium on activated charcoal; In dichloromethane; ethyl acetate; butanone;
DOI:10.1021/jm00022a006