Technology Process of 5-(p-methoxyphenyl)benzoxepine
There total 9 articles about 5-(p-methoxyphenyl)benzoxepine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetrafluoroboric acid;
In
dichloromethane; acetic acid;
for 12h;
Mechanism;
Ambient temperature;
other electrophiles and other o-(aryloxy)phenylalkynes;
- Guidance literature:
-
1-bromo-4-methoxy-benzene;
With
n-butyllithium;
In
tetrahydrofuran;
at -70 ℃;
for 0.5h;
Inert atmosphere;
11H-dibenzo[b,f]oxepin-10-one;
In
tetrahydrofuran;
at 20 ℃;
Inert atmosphere;
DOI:10.1016/j.ejmech.2015.05.035
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: caesium carbonate / N,N-dimethyl acetamide / 2 h / 150 °C
2.1: sodium tetrahydroborate / methanol / 0 - 20 °C
3.1: thionyl chloride; pyridine / benzene / 24 h / Reflux
4.1: dimethyl sulfoxide / 24 h / 20 °C
5.1: potassium hydroxide / ethanol; water / 4 h / Reflux
6.1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 0.5 h
6.2: 1 h / 20 °C
7.1: n-butyllithium / tetrahydrofuran / 0.5 h / -70 °C / Inert atmosphere
7.2: 20 °C / Inert atmosphere
With
pyridine; sodium tetrahydroborate; n-butyllithium; thionyl chloride; oxalyl dichloride; caesium carbonate; potassium hydroxide;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl acetamide; water; dimethyl sulfoxide; N,N-dimethyl-formamide; benzene;
DOI:10.1016/j.ejmech.2015.05.035
