N-acetyl-3-(4-methoxyphenyl)-3-methyl-5-nitroindoline

Base Information

Chemical Name:N-acetyl-3-(4-methoxyphenyl)-3-methyl-5-nitroindoline
CAS No.:1640122-63-9
Molecular Formula:C₁₈H₁₈N₂O₄
Molecular Weight:326.352
Hs Code.:

Synonyms:N-acetyl-3-(4-methoxyphenyl)-3-methyl-5-nitroindoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-acetyl-3-(4-methoxyphenyl)-3-methyl-5-nitroindoline

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Technology Process of N-acetyl-3-(4-methoxyphenyl)-3-methyl-5-nitroindoline

There total 7 articles about N-acetyl-3-(4-methoxyphenyl)-3-methyl-5-nitroindoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1640122-49-1
1-acetyl-3-methyl-5-nitroindole

: 100-66-3
methoxybenzene

: 1640122-63-9
N-acetyl-3-(4-methoxyphenyl)-3-methyl-5-nitroindoline

Guidance literature:: With iron(III) chloride; In dichloromethane; at 20 ℃; for 12h; regioselective reaction;
DOI:10.1002/chem.201400284

Reference yield:

: 6146-52-7
5-nitroindole

: 1640122-63-9
N-acetyl-3-(4-methoxyphenyl)-3-methyl-5-nitroindoline

Guidance literature:: Multi-step reaction with 5 steps

1: trichlorophosphate / 0.5 h / 0 - 20 °C

2: toluene-4-sulfonic acid / N,N-dimethyl-formamide; sulfolane / 1 h / 100 °C

3: sodium cyanoborohydride / 2 h / 100 °C

4: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / dichloromethane / 2.5 h / 20 °C

5: iron(III) chloride / dichloromethane / 12 h / 20 °C

With iron(III) chloride; tetra(n-butyl)ammonium hydrogensulfate; sodium cyanoborohydride; toluene-4-sulfonic acid; sodium hydroxide; trichlorophosphate; In sulfolane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/chem.201400284

Reference yield:

: 6625-96-3
5-nitro-1H-indole-3-carbaldehyde

: 1640122-63-9
N-acetyl-3-(4-methoxyphenyl)-3-methyl-5-nitroindoline

Guidance literature:: Multi-step reaction with 4 steps

1: toluene-4-sulfonic acid / N,N-dimethyl-formamide; sulfolane / 1 h / 100 °C

2: sodium cyanoborohydride / 2 h / 100 °C

3: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / dichloromethane / 2.5 h / 20 °C

4: iron(III) chloride / dichloromethane / 12 h / 20 °C

With iron(III) chloride; tetra(n-butyl)ammonium hydrogensulfate; sodium cyanoborohydride; toluene-4-sulfonic acid; sodium hydroxide; In sulfolane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/chem.201400284